2,2',3,4,4',5-Hexabromobiphenyl
Grundinformationen
- CAS
81381-52-4- Standard-SMILES
Brc1ccc(-c2cc(Br)c(Br)c(Br)c2Br)c(Br)c1- InChIKey
YDEZWWIXWTUKGY-UHFFFAOYSA-N- Summenformel
- C12H4Br6
- Durchschnittliche Molmasse
- 627,6 g/mol
- Monoisotopische Masse
- 621,54133
Überblick
2,2',3,4,4',5'-Hexabromobiphenyl is a polybrominated biphenyl. Polybrominated biphenyls (PBBs) are a group of 209 synthetic organic compounds with 1-10 bromine atoms attached to biphenyl. They can be used as flame retardants and may be added to the plastics used to make products like computer monitors, televisions, textiles, and plastic foams to make them difficult to burn. However, the use of PBBs is banned or restricted in most areas due to their toxicity and persistence in the environment. (L628, L629)
Namen und Bezeichner
- Bevorzugter Name
- 2,2',3,4,4',5-Hexabromobiphenyl
- IUPAC
- 1,2,3,4-tetrabromo-5-(2,4-dibromophenyl)benzene
Namen und Synonyme
2,2',3,4,4',5-Hexabromobiphenyl2,2',3,4,4',5-Hexabromo-1,1'-biphenyl1,2,3,4-tetrabromo-5-(2,4-dibromophenyl)benzeneUNII-595V18DW0W1,1'-Biphenyl, 2,2',3,4,4',5-hexabromo-595V18DW0WDTXSID50231069PBB 137RefChem:80591DTXCID00153560DTXCID901406061,2,3-tribromo-4-(2,4,5-tribromophenyl)benzene
Weitere Namen anzeigen
2,2',3,4,4',5'-Hexabromo-1,1'-biphenyl2,2',3,4,4',5'-HEXABROMOBIPHENYLDTXSID70218115HLP7745GYSPBB 138UNII-HLP7745GYS81381-52-41,1-Biphenyl, 2,2,3,4,4,5-hexabromo-
Datenbank-Bezeichner
- CAS
81381-52-4- PubChem CID
- 154478
- DTXSID
DTXSID50231069- UNII
- 595V18DW0W
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 7,7
- Polarare Oberfläche (TPSA)
- 0 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 0
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 18
- Formalladung
- 0
- Komplexität
- 286
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheit und Schutzausrüstung
Minimum Risk Level
Acute Oral: 0.01 mg/kg/day (L134)
Acute Oral: 0.01 mg/kg/day (L134)
Toxikologische Informationen
Treatment
EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.
EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.
Health Effects
PBB exposure may cause weight loss, skin disorders (such as acne), nervous and immune systems effects, and effects on the liver, kidneys, and thyroid gland. (L628)
PBB exposure may cause weight loss, skin disorders (such as acne), nervous and immune systems effects, and effects on the liver, kidneys, and thyroid gland. (L628)
Exposure Routes
Oral (L628) ; inhalation (L628) ; dermal (L628)
Oral (L628) ; inhalation (L628) ; dermal (L628)
Chemie und Industrie
Pharmakologische Informationen
Metabolism/Metabolites
PBBs can be absorbed via oral, inhalation, and dermal routes. Due to their lipophilic nature, PBBs, especially the highly brominated congeners, tend to accumulate in lipid-rich tissues such as the liver, adipose, skin, and breast milk. Certain PBB compounds are metabolized by the microsomal monooxygenase system catalyzed by cytochrome P-450 of the type induced by phenobarbital. The rate of metabolism may depends on the bromine substitution pattern. PBB congeners of low bromine content are transformed into hydroxylated derivatives that are predominately eliminated in the urine. Highly brominated congeners are either retained or excreted unchanged in the feces. (L628)
PBBs can be absorbed via oral, inhalation, and dermal routes. Due to their lipophilic nature, PBBs, especially the highly brominated congeners, tend to accumulate in lipid-rich tissues such as the liver, adipose, skin, and breast milk. Certain PBB compounds are metabolized by the microsomal monooxygenase system catalyzed by cytochrome P-450 of the type induced by phenobarbital. The rate of metabolism may depends on the bromine substitution pattern. PBB congeners of low bromine content are transformed into hydroxylated derivatives that are predominately eliminated in the urine. Highly brominated congeners are either retained or excreted unchanged in the feces. (L628)
Verwendung und Herstellung
Uses
PBBs can be used as flame retardants and may be added to the plastics used to make products like computer monitors, televisions, textiles, and plastic foams to make them difficult to burn. However, the use of PBBs is banned or restricted in most areas due to their toxicity and persistence in the environment. (L628, L629)
PBBs can be used as flame retardants and may be added to the plastics used to make products like computer monitors, televisions, textiles, and plastic foams to make them difficult to burn. However, the use of PBBs is banned or restricted in most areas due to their toxicity and persistence in the environment. (L628, L629)
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