Lirafugratinib
Grundinformationen
- CAS
2549174-42-5- Standard-SMILES
C=C(C)C(=O)Nc1ccc(-c2c(-c3ccc(Oc4nccc(C)n4)c(F)c3)c3c(N)ncnc3n2C)cc1- InChIKey
XOQVZSSDIQQUGO-UHFFFAOYSA-N- Summenformel
- C28H24FN7O2
- Durchschnittliche Molmasse
- 509,5 g/mol
- Monoisotopische Masse
- 509,1975512
Überblick
Lirafugratinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity. Upon oral administration, lirafugratinib binds to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival.
Namen und Bezeichner
- Bevorzugter Name
- Lirafugratinib
- IUPAC
- N-[4-[4-amino-5-[3-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-methylpyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methylprop-2-enamide
- Englischer Name
- 2-Propenamide, N-[4-[4-amino-5-[3-fluoro-4-[(4-methyl-2-pyrimidinyl)oxy]phenyl]-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methyl-
- Summenformel
- C28H24FN7O2
- Molmasse
- 509.55
Namen und Synonyme
Lirafugratinib2549174-42-5RLY-4008RLY40087HY6IMH87SN-(4-(4-amino-5-(3-fluoro-4-((4-methylpyrimidin-2-yl)oxy)phenyl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)methacrylamideRly 4008N-[4-[4-amino-5-[3-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-methylpyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methylprop-2-enamideexample 343 [WO2020231990A1]2-Propenamide, N-(4-(4-amino-5-(3-fluoro-4-((4-methyl-2-pyrimidinyl)oxy)phenyl)-7-methyl-7H-pyrrolo(2,3-d)pyrimidin-6-yl)phenyl)-2-methyl-2-Propenamide, N-[4-[4-amino-5-[3-fluoro-4-[(4-methyl-2-pyrimidinyl)oxy]phenyl]-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methyl-N-[4-(4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylprop-2-enamide
Weitere Namen anzeigen
FGFR2IN3Lirafugratinib ImpurityFGFR2-IN-3, 10 mM in DMSOLirafugratinib Impurity 1
example 343 (WO2020231990A1)N-(4-(4-amino-5-(3-fluoro-4-((4-methylpyrimidin-2-yl)oxy)phenyl)-7-methyl-7H-pyrrolo(2,3-d)pyrimidin-6-yl)phenyl)-2-methylprop-2-enamideN-(4-(4-amino-5-(3-fluoro-4-((4-methylpyrimidin-2-yl)oxy)phenyl)-7-methyl-7H-pyrrolo(2,3-d)pyrimidin-6-yl)phenyl)methacrylamideN-(4-(4-amino-5-(3-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl)-7-methylpyrrolo(2,3-d)pyrimidin-6-yl)phenyl)-2-methylprop-2-enamideRefChem:153645FGFR2 Inhibitor RLY-4008Fibroblast Growth Factor Receptor 2 Inhibitor RLY-4008FGFR2-IN-3
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 4,3
- Polarare Oberfläche (TPSA)
- 121 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 38
- Formalladung
- 0
- Komplexität
- 840
Physikochemische Eigenschaften
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 62.5 mg/mL · DMSO : 62.5 mg/mL (122.66 mM; ultrasonic and warming and heat to 60°C)
- Aggregatzustand
- Solid
- Farbe
- Off-white to light yellow
- InChIKey
- XOQVZSSDIQQUGO-UHFFFAOYSA-N
- SMILES
- CN1C2=NC=NC(N)=C2C(C2C=CC(OC3=NC=CC(C)=N3)=C(F)C=2)=C1C1C=CC(NC(=O)C(=C)C)=CC=1
Chemie und Industrie
Anbieter29 Anbieter
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
常州博瑞生物科技有限公司13656121842 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
济南德迈医药科技有限公司18669728830 15806766175 · [email protected]
学研惠（武汉）科技有限公司15727060112 · [email protected]
NANJING YINGWEN BIOTECHNOLOGY CO LTD+8613382787392 · [email protected]
湖北扬信医药科技有限公司0714-3999001 19171453112 · [email protected]
Moxin Chemicals+86-17320513646 +86-17320513646 · [email protected]
上海喀露蓝科技有限公司18149758185 18149758185 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
深圳摩科生化科技有限公司18627923403 · [email protected]
苏州美迪森诺医药科技有限公司13771642864 · [email protected]
青岛海智微元生物科技有限公司18317699790 18317699790 · [email protected]
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