Chloridazon

Chloridazon · PYRAZON · Phenazon · Chloridazone · Trojan · Gladiator · Copolymer of Phosphono and carboxylic Acid · 5-Amino-4-chloro-2-phenylpyridazin-3(2H)-one

https://huagongshe.com/de/chemical/15546

Identifikatoren & physikalische Daten

CAS No.	1698-60-8
Summenformel	C10H8ClN3O
Durchschnittliche Molmasse	221,64 g/mol
Monoisotopische Masse	221,0355896 g/mol
SMILES	Nc1cnn(-c2ccccc2)c(=O)c1Cl
InChIKey	WYKYKTKDBLFHCY-UHFFFAOYSA-N
PubChem CID	15546
ChEMBL	CHEMBL1525705
ChEBI	CHEBI:81838
EC No.	216-920-2
DTXSID	DTXSID3034872
Lokaler Name	Chloridazon

Chemische & physikalische Eigenschaften

XLogP	0,8
Polarare Oberfläche (TPSA)	58,7
H-Brücken-Donoren	1
H-Brücken-Akzeptoren	3
Frei drehbare Bindungen	1
Schwere Atome	15
Formalladung	0
Komplexität	332
SpringerMaterials Properties	Fusion temperature
Pestizide	HerbicidesActive substance -> EU Pesticides database: Not approvedPesticides -> Herbicides, OtherPesticides -> Herbicides -> Pyridazinone herbicidesEnvironmental transformation -> Pesticides (parent, predecessor)
LogP (Verteilungskoeffizient)	log Kow = 1.141.19
Geruch	Odorless
Dichte	1.54 g/cu cm at 20 °C1.4884 (rough estimate)
Color/Form	Colorless solid
Löslichkeit	IN WATER 400 MG/L AT 20 °CIN METHANOL 34 G/KG AT 20 °CIN ACETONE 28 G/KG AT 20 °CIN BENZENE 0.7 G/KG AT 20 °CIN CYCLOHEXANE GREATER THAN 0.01 G/100 G @ 20 °CIN CHLOROFORM 0.21 G/100 G @ 20 °CIN ETHER 0.07 G/100 G @ 20 °CIn distilled water, 340 mg/L at 20 °CIn methanol 15.1, ethyl acetate 3.7, dichloromethane 1.9, toluene 0.1 (all in g/l at 20 °C)Practically insoluble in n-hexane.In water, 400 mg/L at 20 °C25.5 [ug/mL] (The mean of the results at pH 7.4)Chloroform (Slightlly), DMSO (Sparingly), Methanol (Slightly)0.3g/L(20 ºC)
Corrosivity	NONCORROSIVE
Human Drugs	Pharmaceuticals
Schmelzpunkt	206 °CMELTING POINT: 185-195 °C /TECHNICAL PRODUCT/Brown, almost odorless. MP: 198-202 °C /technical/198-200°C
Dampfdruck	0.00000045 [mmHg]4.50X10-7 mm Hg at 20 °C
Physical Description	Colorless odorless solid[HSDB]
Siedepunkt	312.2±52.0 °C(Predicted)
Brechungsindex	1.5330 (estimate)
Lagerbedingungen	Keep in dark place,Inert atmosphere,2-8°C
Aggregatzustand	Solid
pKa (Säurekonstante)	0.71±0.20(Predicted)
Farbe	Pale-yellowish solid
BRN	397241
Henry-Konstante	3.0×104 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
InChI	InChI=1S/C10H8ClN3O/c11-9-8(12)6-13-14(10(9)15)7-4-2-1-3-5-7/h1-6H,12H2
InChIKey	WYKYKTKDBLFHCY-UHFFFAOYSA-N
SMILES	C1(=O)N(C2=CC=CC=C2)N=CC(N)=C1Cl
LogP (Verteilungskoeffizient)	1.140
CAS Datenbank	1698-60-8(CAS DataBase Reference)
EPA chemische Informationen	Pyrazon (1698-60-8)

Sicherheit & Vorschriften

GHS-Einstufung	WarningH317: May cause an allergic skin reaction [Warning Sensitization, Skin]P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement)H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
Regulatorische Informationen	Commission Regulation (EC) No 1490/2002Pyrazon is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)2008/41, Reg. (EU) 2022/801, Reg. (EU) No 540/2011Chloridazon: Does not have an individual approval but may be used under an appropriate group standard
Weitere Sicherheitsinformationen	IMAP assessments - 3(2H)-Pyridazinone, 5-amino-4-chloro-2-phenyl-: Environment tier I assessment
Brandpotenzial	DRY POWDER, NONFLAMMABLE.
Gefahrenübersicht	Repeated exposure may cause skin rashesCase reports of slight liver enlargement[HSDB] May cause skin sensitization[eChemPortal: ESIS] May cause irritationMay cause skin sensitization[MSDSonline]
Special Reports	USEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - Pyrazon EPA 738-F-05-014 (September 2005). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of February 27, 2007: http://www.epa.gov/pesticides/reregistration/status.htm]
FIFRA-Anforderungen	Tolerances are established for combined residues of the herbicide pyrazon (5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone) and its metabolites (calculated as pyrazon) in or on the following food commodities: [Table#3543]The Agency made its reregistration eligibility determination based on the required data, the current guidelines for conducting acceptable studies to generate such data, and published scientific literature. The Agency has found that currently registered uses of pyrazon are eligible for reregistration.

Anwendungen & Verwendung

Verwenden

Herbicide, active by perturbing cell membranes