Concanavalin A
Grundinformationen
- CAS
11028-71-0- Standard-SMILES
CCCN(CCC)S(=O)(=O)c1ccc(C(=O)O)cc1.Cc1cn(C2CC(N=[N+]=[N-])C(CO)O2)c(=O)[nH]c1=O- InChIKey
RVSZVJZFCQZYHQ-UHFFFAOYSA-N- Summenformel
- C23H32N6O8S
- Durchschnittliche Molmasse
- 552,6 g/mol
- Monoisotopische Masse
- 552,20023317
Überblick
Concanavalin A is an organic molecular entity.
Namen und Bezeichner
- Bevorzugter Name
- Concanavalin A
- IUPAC
- 1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione;4-(dipropylsulfamoyl)benzoic acid
- Lokaler Name
- Concanavalin A
- Englischer Name
- Concanavalin A
- Summenformel
- C15H24
- Molmasse
- 0
Namen und Synonyme
CONCANAVALIN A11028-71-0Concanavaline ARicintoxin con ACon-ARicin-toxin con ACON ARefChem:388895DTXSID3037202EINECS 234-258-2NSC 143504234-258-2
Weitere Namen anzeigen
nsc143504Con A/Cy5.5CONCANAVALINCON A TYPE IVA,concanavalinconcanavalineaCONCANAVALIN A TYPEConcanavalin A III
Concanavalin A lectin (Con A)CONCANAVALIN A TYPE IIIConA Type A IVConcanavalin A from Canavalia ensiformis (jack bean)UltraBio? Concanavalin A Magnetic Beads (1|Im)1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione;4-(dipropylsulfamoyl)benzoic acidorb1303318SCHEMBL27467489
Datenbank-Bezeichner
- CAS
11028-71-0- PubChem CID
- 155486958
- ChEBI
CHEBI:232423- EC Number
- 234-258-2
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 176 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 11
- Frei drehbare Bindungen
- 10
- Schwere Atome
- 38
- Formalladung
- 0
- Komplexität
- 858
Experimentelle und physikochemische Eigenschaften
Chemical ClassesOther Uses -> Biochemical Research
Physical DescriptionLyophilized powder; [Sigma-Aldrich MSDS]
Physikochemische Eigenschaften
- Flammpunkt
- 39 °C · 39 °C
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- 5 mg/mL, · PBS: 5 mg/mL, slightly hazy
- Aggregatzustand
- powder
- Farbe
- White to light yellow
- Biologische Quelle
- Canavalia ensiformis (jack bean)
- Wasserlöslichkeit
- Slightly soluble in water and phosfate buffered saline.
- CAS Datenbank
- 11028 · 11028-71-0
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P203, P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P318, P321, P333+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 7 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: Concanavalin A
Concanavalin A: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Concanavalin A: Environment tier I assessment
Hazards Summary
Teratogenic effects observed in rabbits (intraperitoneal) and mice (intravenous) exposed during gestation; [Shepard's Catalog of Teratogenic Agents] Causes diffuse hepatitis and changes in thymus and spleen weights in acute intravenous studies of mice; Causes decreased cellular immune response in 30-day intermittent intraperitoneal studies of mice; [RTECS] May cause irritation; May cause skin and respiratory sensitization; May cause toxicity to human reproduction; [Sigma-Aldrich MSDS] PubMed: no results for 11028-71-0 AND (allergic OR sensitizer OR sensitization OR asthma)[Title];
Hazard Classes and CategoriesSkin Sens. 1 (100%)
Toxikologische Informationen
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Substances that stimulate mitosis and lymphocyte transformation. They include not only substances associated with LECTINS, but also substances from streptococci (associated with streptolysin S) and from strains of alpha-toxin-producing staphylococci. (Stedman, 25th ed)
Verwendung und Herstellung
UsesA plant protein in the lectin family; Isolated from jack beans; Used as a biochemical reagent and as a probe in cell biology (membrane dynamics and cell division); [Merck Index]
Anwendungen
VerwendenConcanavalin A is a unique lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis. Concanavalin A specifically binds to α-mannose and α-galactose structures found in sugars, glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures. At 20 mg/kg concanavalin A is also used to induce liver injury in experimental mouse models of autoimmune hepatitis in order to study immune regulation by macrophages and T cells. Concanavalin A is toxic to several tumor cell lines and has been reported to induce programmed cell death of cortical neurons by a mechanism similar to that of the amyloid β peptide.
Anbieter100 Anbieter
北京华美互利生物化工010-56205725 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司
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