62928-11-4CC(C)N.CC(C)N.[Cl-].[Cl-].[OH-].[OH-].[Pt]AGFPKKCNKJRESC-UHFFFAOYSA-JIproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. (NCI04)
62928-11-4Substances that inhibit or prevent the proliferation of NEOPLASMS.
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
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