Cinacalcet Hydrochloride

HCID 156418

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Grundinformationen

CAS: 364782-34-3
Standard-SMILES: C[C@@H](NCCCc1cccc(C(F)(F)F)c1)c1cccc2ccccc12.Cl
InChIKey: QANQWUQOEJZMLL-PKLMIRHRSA-N
Summenformel: C22H23ClF3N
Durchschnittliche Molmasse: 393,9 g/mol
Monoisotopische Masse: 393,14711208

Überblick

Cinacalcet hydrochloride is a hydrochloride derived from equimolar amounts of cinacalcet and hydrogen chloride. It has a role as a calcimimetic and a P450 inhibitor. It is functionally related to a cinacalcet.

Namen und Bezeichner

Bevorzugter Name: Cinacalcet Hydrochloride
IUPAC: N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine;hydrochloride

Namen und Synonyme

Cinacalcet hydrochloride364782-34-3Cinacalcet HClMimparaAMG073 HClDTXSID3046792AMG-073 HCLAMG073 hydrochloride1K860WSG25DTXCID1026792CHEBI:483911-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, Hydrochloride

Weitere Namen anzeigen

RefChem:57402620-490-5Sensipar(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochlorideRegparaCinacalcet hydrochloride [USAN]MFCD08067750CNC-HCl

Datenbank-Bezeichner

CAS: 364782-34-3
PubChem CID: 156418
DTXSID: DTXSID3046792
ChEMBL: CHEMBL1200776
ChEBI: CHEBI:48391
UNII: 1K860WSG25
EC Number: 620-490-5

Eigenschaften

Berechnete StruktureigenschaftenWird ergänzt

Polarare Oberfläche (TPSA): 12 Å²
H-Brücken-Donoren: 2
H-Brücken-Akzeptoren: 4
Frei drehbare Bindungen: 6
Schwere Atome: 27
Formalladung: 0
Komplexität: 422

Experimentelle und physikochemische Eigenschaften

Human Drugs · 5 Einträge

Breast Feeding; Lactation; Milk, Human; Calcium-Regulating Hormones and Agents; Calcimimetic Agents

FDA approved drugs -> Active ingredient

EMA approved medicines: Human medicine

FDA approved drugs -> Active ingredient

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 9.1% (1 of 11) of reports.

Danger

H302 (45.5%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P333+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 11 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Hazard Classes and CategoriesAcute Tox. 4 (45.5%)

Toxikologische Informationen

Drug Induced Liver Injury · 6 Einträge

Drug Induced Liver Injury Rank (DILIrank 2.0)

Cinacalcet hydrochloride

vNo-DILI-concern

No match

DOI:10.1016/j.drudis.2016.02.015

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 2 Einträge

CINACALCET HYDROCHLORIDE

Calcium-sensing Receptor Agonist [EPC]; Increased Calcium-sensing Receptor Sensitivity [MoA]

MeSH Pharmacological Classification · 2 Einträge

Hormones and molecules with calcium-regulating hormone-like actions that modulate OSTEOLYSIS and other extra-skeletal activities to maintain calcium homeostasis.

Small organic molecules that act as allosteric activators of the calcium sensing receptor (CaSR) in the PARATHYROID GLANDS and other tissues. They lower the threshold for CaSR activation by extracellular calcium ions and diminish PARATHYROID HORMONE (PTH) release from parathyroid cells.