Protectin D1
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Grundinformationen
- CAS
660430-03-5- Standard-SMILES
CC/C=C\C[C@H](O)\C=C/C=C/C=C/[C@H](O)C/C=C\C/C=C\CCC(=O)O- InChIKey
CRDZYJSQHCXHEG-SFVBTVKNSA-N- Summenformel
- C22H32O4
- Durchschnittliche Molmasse
- 360,494 g/mol
- Monoisotopische Masse
- 360,2300595
Namen und Bezeichner
- Bevorzugter Name
- Protectin D1
- Englischer Name
- Protectin D1
- Summenformel
- C22H32O4
- Molmasse
- 360.49
Namen und Synonyme
NPD1Protectin D1Protectin D-1,Protectin D14,7,11,13,15,19-Docosahexaenoic acid, 10,17-dihydroxy-, (4Z,7Z,10R,11E,13E,15Z,17S,19Z)-
Datenbank-Bezeichner
- CAS
660430-03-5- PubChem CID
- 16042541
- DTXSID
DTXSID101031663- ChEMBL
CHEMBL3234407- ChEBI
CHEBI:138655- UNII
- P3FX063KLI
- Nikkaji
- J2.417.900A
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 559.4 · 559.4±50.0 °C(Predicted)
- Dichte
- 1.048 · 1.048±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 50 mg/ml; · DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.1 mg/ml
- Aggregatzustand
- Liquid
- pka
- 4.58 · 4.58±0.10(Predicted)
- Farbe
- Colorless to light yellow
Chemie und Industrie
Anwendungen
BeschreibungProtectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ). DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a non-phlogistic manner and is generated in vitro during macrophage-apoptotic interactions. It enhances phagocytosis in mice after 24 hours, but not at the initiation or peak of inflammation. It also decreases PMN infiltration in a zymosan-induced mouse model of inflammation when administered at a dose of 300 ng per animal. Protectin D1 (200 μg, i.v.) inhibits increases in neutrophil counts in bronchoalveolar fluid (BALF) and lung myeloperoxidase activity in a mouse model of pulmonary injury and inflammation induced by intratracheal LPS instillation. It also decreases pulmonary edema and promotes neutrophil apoptosis in BALF.
VerwendenProtectin D1 is a potent anti-inflammatory lipid mediator.
Anbieter8 Anbieter
北京百奥创新科技有限公司15522676233 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海宏叶生物科技有限公司400-9205774 400-920-5774 · [email protected]
ChemeGen 中国18818260767 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
上海阿摩尔生物科技有限公司13370042665 18916960931 · [email protected]
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