Resolvin D5
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Grundinformationen
- CAS
578008-43-2- Standard-SMILES
CC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C=C\[C@@H](O)/C=C\CCCC(=O)O- InChIKey
JBRPFYYLEQERPG-XTIXYJHRSA-N- Summenformel
- C22H32O4
- Durchschnittliche Molmasse
- 360,494 g/mol
- Monoisotopische Masse
- 360,2300595
Namen und Bezeichner
- Bevorzugter Name
- Resolvin D5
- Englischer Name
- Resolvin D5
- Summenformel
- C22H32O4
- Molmasse
- 360.49
Namen und Synonyme
Resolvin D57(S),17(S)-Resolvin D5(5Z,7S,8E,10Z,13Z,15E,17S,19Z)-7,17-dihydroxydocosa-5,8,10,13,15,19-hexaenoic acid4,8,10,13,15,19-Docosahexaenoic acid, 7,17-dihydroxy-, (4Z,7S,8E,10Z,13Z,15E,17S,19Z)-
Datenbank-Bezeichner
- CAS
578008-43-2- PubChem CID
- 16061139
- DTXSID
DTXSID501354025- ChEBI
CHEBI:138645
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 559.4 · 559.4±50.0 °C(Predicted)
- Dichte
- 1.048 · 1.048±0.06 g/cm3(Predicted)
- storage temp.
- -80 °C,protect · Store at -80°C,protect from light
- Löslichkeit
- 50 mg/ml; · DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.5 mg/ml
- pka
- 4.58 · 4.58±0.10(Predicted)
- Kosmetik-Inhaltsstoffe Funktionen
- SKIN PROTECTING
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- Alarmwort
- Achtung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H225
Chemie und Industrie
Anwendungen
BeschreibungResolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; ) and docosahexaenoic acid (DHA; ). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; ) and docosahexaenoic acid (DHA; ). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D5 (RvD5) is a DHA-derived resolvin generated by a double dioxygenation mechanism. RvD5 has been identified in media from ionophore-stimulated trout brain cells, in human synovial fluid from patients with rheumatoid arthritis, and in exudates of bacterial infections in mice. RvD5 stimulates the phagocytosis of E. coli by human macrophages, and RvD5 methyl ester enhances bacterial killing in mice inoculated with E. coli. Analytical and biological comparisons of synthetic RvD5 with endogenously derived RvD5 have confirmed its identity as matching the natural product.
Verwenden7(S),17(S)-Resolvin D5 is a docosahexaenoic acid (D494500), which is a ω-3 fatty acid that is found in the brain, synapses, and retina. It also exhibits anti-inflammatory activity.
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