Kibdelone C
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Grundinformationen
- CAS
934464-79-6- Standard-SMILES
CCCc1c(Cl)c2c(O)c3c(c(O)c2c(=O)n1C)-c1c(c(OC)c2oc4c(c(=O)c2c1O)[C@@H](O)[C@@H](O)C[C@@H]4O)CC3- InChIKey
NEZGGHIIKFHZCZ-MZFXBISCSA-N- Summenformel
- C29H28ClNO10
- Durchschnittliche Molmasse
- 585,993 g/mol
- Monoisotopische Masse
- 585,14017378
Namen und Bezeichner
- Bevorzugter Name
- Kibdelone C
- Englischer Name
- Kibdelone C
- Summenformel
- C29H28ClNO10
- Molmasse
- 585.99
Namen und Synonyme
Kibdelone C2H-[1]Benzopyrano[2',3':6,7]naphth[2,1-g]isoquinoline-1,14-dione, 4-chloro-6,7,10,11,12,13-hexahydro-5,10,12,13,15,16-hexahydroxy-8-methoxy-2-methyl-3-propyl-, (10S,12S,13R)-
Datenbank-Bezeichner
- CAS
934464-79-6- PubChem CID
- 16109693
- DTXSID
DTXSID501043886- Nikkaji
- J2.447.739H
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 265 · 265-267 °C(Solv: benzene (71-43-2))
- Siedepunkt
- 968.8 · 968.8±65.0 °C(Predicted)
- Dichte
- 1.71 · 1.71±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
- Aggregatzustand
- A solid
- pka
- 6.44 · 6.44±0.70(Predicted)
Chemie und Industrie
Anwendungen
BeschreibungKibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro.
VerwendenKibdelone C is the major analogue of a potent antitumour complex isolated from Kibdelosporangium sp.. Structurally, kibdelone C is related to lysolipin and albofungin, however no comparative investigation of this class has been reported. The mode of action and pharmacology of the kibdelones has received little attention.
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