MOTILIN (HUMAN, PORCINE)
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Grundinformationen
- CAS
52906-92-0- Standard-SMILES
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O- InChIKey
LVRVABPNVHYXRT-BQWXUCBYSA-N- Summenformel
- C120H188N34O35S
- Durchschnittliche Molmasse
- 2.699,05 g/mol
Namen und Bezeichner
- Bevorzugter Name
- MOTILIN (HUMAN, PORCINE)
- Englischer Name
- MOTILIN (HUMAN, PORCINE)
- Summenformel
- C120H188N34O35S
- Molmasse
- 2699.05
Namen und Synonyme
Motilin(pig)Motilin (swine)MOTILIN (HUMAN, PORCINE)
Datenbank-Bezeichner
- CAS
52906-92-0、9072-41-7- PubChem CID
- 16136567
- ChEMBL
CHEMBL2372767、CHEMBL525634- Nikkaji
- J506.159H
Eigenschaften
Physikochemische Eigenschaften
- Dichte
- 1.48 · 1.48±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 25 mg/ml; · DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly; PBS (pH 7.2): 5 mg/ml
- Aggregatzustand
- A crystalline solid
Chemie und Industrie
Anwendungen
BeschreibungMotilin is a polypeptide hormone that stimulates gastric motility through release in the small intestine and into the general circulation during fasting. In isolated rabbit duodenal segments, porcine motilin (10 nM-1 μM) induced phasic contractions and acetylcholine release from enteric neurons (EC50 = 2.5 nM). Formulations containing motilin are used to increase gastrointestinal motility in patients with diabetic gastroparesis, often in combination with erythromycin , an antibiotic and agonist at the motilin receptor.
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