Atriopeptin III
Grundinformationen
- CAS
90817-13-3- Standard-SMILES
CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)CSSC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O- InChIKey
AYCBRUDZNRVKGK-GWLSAQFNSA-N- Summenformel
- C107H165N35O34S2
- Durchschnittliche Molmasse
- 2.549,8 g/mol
- Monoisotopische Masse
- 2.548,1699598
Überblick
from mammalian atria; contains 24-amino acid residues corresponding to sequence (103-126) of the ANF prohormone ATRIAL NATRIURETIC FACTOR (1-126), or sequence (127-150) of the ANF PRECURSORS; relaxes intestinal and vascular smooth muscle strips and is a potent natriuretic; amino acid sequence given in first source
Namen und Bezeichner
- Bevorzugter Name
- Atriopeptin III
- IUPAC
- (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(4R,10S,16S,19S,22S,28S,31S,34S,37S,40S,49S,52R)-52-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-19-(3-amino-3-oxopropyl)-49-benzyl-28,37-bis[(2S)-butan-2-yl]-31,40-bis(3-carbamimidamidopropyl)-34-(carboxymethyl)-16-(hydroxymethyl)-22-methyl-10-(2-methylpropyl)-6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-hexadecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecazacyclotripentacontane-4-carbonyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
- Englischer Name
- ATRIOPEPTIN III (RAT)
- Summenformel
- C107H165N35O34S2
- Molmasse
- 2549.8
Namen und Synonyme
Atriopeptin IIIAtriopeptin 24Atriopeptin-24Atriopeptin 3Atriopeptin III rat2Q3V77H73VAtrial natriuretic peptide (103-126)97793-28-7atriopeptin-3RefChem:115513atriopeptin (103-126)atrial natriuretic factor (103-126)
Weitere Namen anzeigen
atriopeptin24ANP (5-28), RATRat atriopeptin-24Atriopeptin-24【rat】ALPHA-ANF 5-28, RATRat atriopeptin IIIAtriopeptin III（TFA）SSCFGGRIDRIGAQSGLGCNSFR
ANF (103-126)ANP (103-126)Atriopeptin III (rat)90817-13-3Atriopeptin III(TFA)orb321433UNII-2Q3V77H73Vorb1941829
Datenbank-Bezeichner
- CAS
90817-13-3、97793-28-7- PubChem CID
- 16142364
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -11,8
- Polarare Oberfläche (TPSA)
- 1.190 Ų
- H-Brücken-Donoren
- 42
- H-Brücken-Akzeptoren
- 40
- Frei drehbare Bindungen
- 53
- Schwere Atome
- 178
- Formalladung
- 0
- Komplexität
- 5.630
Physikochemische Eigenschaften
- Dichte
- 1.54 · 1.54
- storage temp.
- -15 °C · -15°C
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents that promote the excretion of urine through their effects on kidney function.
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