N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
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Grundinformationen
- CAS
119942-99-3- Standard-SMILES
CC(C)C[C@H](NP(=O)([O-])O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)[O-].[Na+].[Na+]- InChIKey
BABZCHDWRMTINB-ODIUWQMJSA-N- Summenformel
- C23H35N3NaO10P
- Durchschnittliche Molmasse
- 567,51 g/mol
Namen und Bezeichner
- Bevorzugter Name
- N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
- Englischer Name
- N-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)
- Summenformel
- C23H35N3NaO10P
- Molmasse
- 567.51
Namen und Synonyme
Phosphoramidon (Disodium)CRDWMOVRQCMROH-HIKRQZGHSA-NN-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium saltN-[N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]- L-tryptophan,sodium salt (1:1)Sodium (oxido(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phosphoryl)-L-leucyl-L-tryptophanate
Datenbank-Bezeichner
- CAS
119942-99-3、164204-38-0- PubChem CID
- 16219931
- ChEMBL
CHEMBL1257059、CHEMBL2028192- UNII
- 3F7O684NXF
- EC Number
- 805-359-4
Eigenschaften
Physikochemische Eigenschaften
- storage temp.
- -20 °C · Desiccate at -20°C
- Löslichkeit
- 58.7 mg/mL · ≥58.7 mg/mL in DMSO; insoluble in EtOH; ≥52.5 mg/mL in H2O
- Aggregatzustand
- solid
- Farbe
- White to off-white
- Wasserlöslichkeit
- 100 mM · Soluble to 100 mM in water
Chemie und Industrie
Anwendungen
BeschreibungNeprilysin (NEP) and NEP2 are membrane-bound zinc metalloproteases. Phosphoramidon is a natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes. It is also a weak inhibitor of the related zinc metalloprotease endothelin-converting enzyme (Ki = 3.5 μM). Phosphoramidon has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin, and angiotensin-converting enzyme.
VerwendenAn endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.
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