13,14-Dihydro-15-keto-PGE1
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Grundinformationen
- CAS
5094-14-4- Standard-SMILES
CCCCCC(=O)CC[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O- InChIKey
CDUVSQMTLOYKTR-ZHALLVOQSA-N- Summenformel
- C20H34O5
- Durchschnittliche Molmasse
- 354,487 g/mol
- Monoisotopische Masse
- 354,24062419
Namen und Bezeichner
- Bevorzugter Name
- 13,14-Dihydro-15-keto-PGE1
- IUPAC
- 11alpha-Hydroxy-9,15-dioxoprostan-1-oic acid
- Englischer Name
- 13,14-Dihydro-15-keto prostaglandin E1
- Summenformel
- C20H34O5
- Molmasse
- 354.49
Namen und Synonyme
U 2100213,14-dihydro-15-keto PGE1CDUVSQMTLOYKTR-ZHALLVOQSA-N13,14-Dihydro-15-keto prostaglandin E19,15-dioxo-11α-hydroxy-prostan-1-oic acid9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACIDProstan-1-oic acid, 11-hydroxy-9,15-dioxo-, (11α)-15-Keto Prostaglandin E0 DISCONTINUED, OFFER K202056
Datenbank-Bezeichner
- CAS
5094-14-4- PubChem CID
- 165284
- DTXSID
DTXSID201311666- ChEBI
CHEBI:134499- UNII
- M3I99MYM0V
- Nikkaji
- J363.761A
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 537.2 · 537.2±35.0 °C(Predicted)
- Dichte
- 1.072 · 1.072±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C Freezer, Under inert atmosphere
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly), THF (Slightly)
- Aggregatzustand
- Oil
- pka
- 4.77 · 4.77±0.10(Predicted)
- Farbe
- Dark Yellow
Chemie und Industrie
Anwendungen
Beschreibung13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 μM, respectively, compared to PGE1 which has an IC50 of 40 nM.
Verwenden15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders.
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