(+)-Menthol
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Grundinformationen
- CAS
15356-60-2- Standard-SMILES
CC(C)[C@H]1CC[C@H](C)C[C@@H]1O- InChIKey
NOOLISFMXDJSKH-AEJSXWLSSA-N- Summenformel
- C10H20O
- Durchschnittliche Molmasse
- 156,26 g/mol
- Monoisotopische Masse
- 156,15141526
Überblick
D,l-menthol is a white crystalline solid with a peppermint odor and taste. (NTP, 1992)
Namen und Bezeichner
- Bevorzugter Name
- (+)-Menthol
- IUPAC
- (1S,2R,5S)-5-methyl-2-propan-2-ylcyclohexan-1-ol
- Lokaler Name
- (+)-Menthol
- Englischer Name
- (+)-MENTHOL
- Summenformel
- C10H20O
- Molmasse
- 156.27
Namen und Synonyme
(+)-Menthol15356-60-2d-Menthol(1S,2R,5S)-(+)-Menthol(1S,2R,5S)-Menthol(1S,2R,5S)-2-Isopropyl-5-methylcyclohexanolCyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)-Menthol, (+)-DTXSID8029733C6B1OE8P3WMenthol, (1S,3S,4R)-(+)-(+)-(1S,2R,5S)-menthol
Weitere Namen anzeigen
C00553(1S,2R,5S)-dextro-mentholD-P-MENTHAN-3-OL(1S)-(+)-menthol(+)-p-Menthan-3-ol(+)-Menthol solution
(+)-(1S,3S,4R)-mentholEINECS 239-387-8MENTHOL, D-DTXCID409733CHEBI:76306EC 239-387-8Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S-(1alpha,2beta,5alpha))-Cryomax Cooling
Datenbank-Bezeichner
- CAS
15356-60-2、15356-70-4、89-78-1- PubChem CID
- 165675
- DTXSID
DTXSID8029733- ChEMBL
CHEMBL2106989、CHEMBL41763- ChEBI
CHEBI:76306- UNII
- C6B1OE8P3W
- EC Number
- 239-387-8、239-388-3
- Nikkaji
- J9.252E
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 3
- Polarare Oberfläche (TPSA)
- 20,2 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 11
- Formalladung
- 0
- Komplexität
- 120
Experimentelle und physikochemische Eigenschaften
Chemical ClassesBiological Agents -> Plant Oils and Extracts
DrugsPharmaceuticals -> Listed in ZINC15
CosmeticsCosmetics ingredient -> Buffering/pH Adjusting; Conditioning/Emollient; Flavor; Fragrance; Other (Specify)
SpringerMaterials PropertiesOptical coefficient
FragrancesFragrance Ingredient (d-Menthol) -> IFRA transparency List
Density
0.904 at 59 °F (NTP, 1992) - Less dense than water; will float
0.901 (20 °C); 0.891 (30 °C)
Solubility
less than 1 mg/mL at 70 °F (NTP, 1992)
very soluble in alcohol and volatile oils; slightly soluble in water
(in ethanol)
Flash Point196 °F (NTP, 1992)
Boiling Point
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1451) of reports.
Warning
H315 (> 99.9%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P280, P302+P352, P321, P332+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 1451 reports by companies from 5 notifications to the ECHA C&L Inventory.
Danger
Gefahrenhinweise
Regulatory Information
Chemical: Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-
Chemical: Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1S-(1.alpha.,2.beta.,5.alpha.)]-
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 13-10-2010 https://echa.europa.eu/registration-dossier/-/registered-dossier/12128
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)-: Does not have an individual approval but may be used under an appropriate group standard
Other Safety Information
IMAP assessments - Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-: Human health tier I assessment
IMAP assessments - Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1S-(1.alpha.,2.beta.,5.alpha.)]-: Human health tier I assessment
Chemie und Industrie
Verwendung und Herstellung
UsesPure form used only for scientific purposes; [OECD SIDS: IUCLID Data Set]
U.S. Production
2023: 1,000,000 - <5,000,000 lb
2023: 1,000,000 - <8,500,000 lb
Consumer UsesFragrance
Industry Uses
Odor agents
Odor agents
Household Products
Cosmetics product ingredient: Menthol (dl-menthol; l-menthol; d-menthol)
Information on 35 consumer products that contain Menthol (Racementhol) in the following categories is provided:
Use Classification
Fragrance Ingredients
Flavoring Agents -> JECFA Flavorings Index
General Manufacturing Information
All Other Basic Organic Chemical Manufacturing
Soap, Cleaning Compound, and Toilet Preparation Manufacturing
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-: ACTIVE
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)-: ACTIVE
Anwendungen
Beschreibung(+)-Menthol is a monoterpene alcohol that has been found in Cannabis and has antifungal activity. It inhibits the growth of F. verticillioides (MIC = 1.5 mM). Unlike (–)-menthol, (+)-menthol does not exhibit analgesia, antibacterial, anticancer, or cholinesterase inhibitory activities.
Verwenden(+)-MENTHOL is used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.
Zugehörige Reaktionen
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