Diphenyl(2,4,6-trimethylbenzoyl)phosphinoxid
2,4,6-Trimethylbenzoyl diphenylphosphine oxide
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Grundinformationen
- CAS
75980-60-8- Standard-SMILES
Cc1cc(C)c(C(=O)P(=O)(c2ccccc2)c2ccccc2)c(C)c1- InChIKey
VFHVQBAGLAREND-UHFFFAOYSA-N- Summenformel
- C22H21O2P
- Durchschnittliche Molmasse
- 348,4 g/mol
- Monoisotopische Masse
- 348,12791654
Namen und Bezeichner
- Bevorzugter Name
- 2,4,6-Trimethylbenzoyl diphenylphosphine oxide
- IUPAC
- diphenylphosphoryl-(2,4,6-trimethylphenyl)methanone
- Lokaler Name
- Diphenyl(2,4,6-trimethylbenzoyl)phosphinoxid
- Englischer Name
- Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
- Summenformel
- C22H21O2P
- Molmasse
- 348.37
Namen und Synonyme
75980-60-8Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxidePhosphine oxide, diphenyl(2,4,6-trimethylbenzoyl)-DTXSID4052502EINECS 278-355-8B9EIM2D97X2,4,6-trimethylbenzoyl diphenylphosphine oxidetrimethylbenzoyl diphenylphosphine oxideCHIVACURE TPODOUBLECURE TPOADDITOL TPOGENOCURE TPO
Weitere Namen anzeigen
Photoinitiator TPOTMDPO(Diphenylphosphoryl)(Mesityl)Methanone2,4,6-TRIMETHYLBENZOYLDIPHENYLPHOSPHINE OXIDEbiphenyl(2,4,6-trimethyl-benzoyl)-phosphine oxide2,4,6-TRIMETHYLBENZOYLDIPHENYL PHOSPHINE OXIDE TPODiphenyl(2,4,6-triMethylbenzoyl)phosphine oxide (TPO)HRcure-TPOSPEEDCURE TPOUV photoinitiator TPO
Methanone, (diphenylphosphinyl)(2,4,6-trimethylphenyl)-DTXCID8031075EC 278-355-8(2,4,6-trimethylbenzoyl)diphenylphosphine oxide(DIPHENYLPHOSPHINYL)(2,4,6-TRIMETHYLPHENYL)METHANONERefChem:442966TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE [INCI]278-355-8
Datenbank-Bezeichner
- CAS
75980-60-8- PubChem CID
- 166480
- DTXSID
DTXSID4052502- ChEMBL
CHEMBL3561198- UNII
- B9EIM2D97X
- EC Number
- 278-355-8
- Nikkaji
- J240.339K
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 5
- Polarare Oberfläche (TPSA)
- 34,1 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 25
- Formalladung
- 0
- Komplexität
- 468
Experimentelle und physikochemische Eigenschaften
CosmeticsCosmetic ingredients (Trimethylbenzoyl Diphenylphosphine Oxide) -> CIR (Cosmetic Ingredient Review)
pH4 to 5
Density1.218 g/cm³ at 20 degrees C (OECD 109)
SolubilityWater solubility: 3.3 mg/L at 20 °C (OECD Guideline 105, Flask method) and 11.9 mg/L at 20 °C (OECD Guideline 105, Column elution). Readily soluble in dichloromethane, acetone, n-butylacetate; soluble in styrene and in other monomers.
Boiling PointGreater than 300 degrees C
Melting Point93 degrees C (OECD Guideline 102)
Vapor Pressure3.045 x 10-6 Pa at 25 degrees C
Physical Description
Large Crystals; Liquid; Liquid; CBI; Dry Powder
Solid (yellow powder)
Stability/Shelf LifeAt least two years (cool and dry; light sensitive, to be stored in the dark)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
P203, P261, P272, P280, P302+P352, P318, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement)
This chemical does not meet GHS hazard criteria for 0.4% (13 of 3088) of reports.
Warning
H317 (12.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]
Gefahrenhinweise
Regulatory Information
Chemical: Phosphine oxide, diphenyl(2,4,6-trimethylbenzoyl)-
Hazard Traits - Reproductive Toxicity
Methanone, (diphenylphosphinyl)(2,4,6-trimethylphenyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methanone, (diphenylphosphinyl)(2,4,6-trimethylphenyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
Status: Active Update: 03-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13110
Substance: diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
Other Safety InformationIMAP assessments - Phosphine oxide, diphenyl(2,4,6-trimethylbenzoyl)-: Human health tier II assessment
Hazard Classes and Categories
Skin Sens. 1 (12.5%)
Reproductive toxicity - category 2
Repr. 1B
Toxikologische Informationen
Toxicity Summary
Chemie und Industrie
Pharmakologische Informationen
Mechanism of Action
A 2021 review describes in detail the mechanism of actionr of trimethylbenzoyl-diphenylphosphine oxide as a type-1 photoinitiator in dental resin composites. It undergoes rapid cleavage from a triplet excited state to yield two radicals (trimethylbenzoyl radical and diphenylphosphinoyl radical) that initiate polymerization.
Verwendung und Herstellung
UsesCIR ingredient: Trimethylbenzoyl Diphenylphosphine Oxide
U.S. Production2023: 1,000,000 - <2,500,000 lb
Consumer Uses
Solvent
The European Commission prohibited the use of TPO in cosmetic products beginning on September 1, 2025 (via the adoption of Commission Regulation (EU) 2025/877). This was the result of TPO being classified as a CMR category 1B reproductive toxicant by Commission Delegated Regulation (EU) 2024/197 under the CLP Regulation (Regulation (EC) No 1272/2008), and this classification triggered the mandatory inclusion of TPO in Annex II (prohibited substances) of the Cosmetics Regulation via Regulation (EU) 2025/877.
Industry Uses
Not Known or Reasonably Ascertainable
A 2021 review describes use as a photoinitiator in dental resin composites.
Household ProductsCosmetics product ingredient: Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (Trimethylbenzoyl diphenylphosphine oxide)
General Manufacturing Information
Printing Ink Manufacturing
Methanone, (diphenylphosphinyl)(2,4,6-trimethylphenyl)-: ACTIVE
Anwendungen
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide is a photo initiator, used in many kinds of ink industries
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