Azd-1480
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Grundinformationen
- CAS
935666-88-9- Standard-SMILES
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)n[nH]1- InChIKey
PDOQBOJDRPLBQU-QMMMGPOBSA-N- Summenformel
- C14H14ClFN8
- Durchschnittliche Molmasse
- 348,76 g/mol
- Monoisotopische Masse
- 348,1013983
Namen und Bezeichner
- Bevorzugter Name
- Azd-1480
- IUPAC
- 5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
- Englischer Name
- AZD 1480
- Summenformel
- C14H14ClFN8
- Molmasse
- 348.77
Namen und Synonyme
AZD1480935666-88-9AZD-1480AZD 1480KL2Z2TLF015-Chloro-N2-[(1s)-1-(5-Fluoropyrimidin-2-Yl)ethyl]-N4-(5-Methyl-1h-Pyrazol-3-Yl)pyrimidine-2,4-DiamineDTXSID502394692,4-Pyrimidinediamine, 5-chloro-N2-((1S)-1-(5-fluoro-2-pyrimidinyl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-5-chloro-2-N-((1S)-1-(5-fluoropyrimidin-2-yl)ethyl)-4-N-(3-methyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(3-methyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine5-chloro-N2-((1S)-1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Weitere Namen anzeigen
AZD1480, >=98%AZD1480 ，S2162AZD-1480, 10 mM in DMSOAZD1480, 98%, a novel ATP-competitive JAK2 inhibitor(S)-5-Chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamin
RefChem:115989DTXCID20161960JAK2 INHIBITOR AZD1480(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamineC14H14ClFN8MFCD160389045-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamineCHEMBL1231124
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 2,4
- Polarare Oberfläche (TPSA)
- 104 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 24
- Formalladung
- 0
- Komplexität
- 397
Physikochemische Eigenschaften
- Schmelzpunkt
- 205 °C · >205°C (dec.)
- Siedepunkt
- 575.2 · 575.2±60.0 °C(Predicted)
- Dichte
- 1.517 · 1.517
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
- Aggregatzustand
- powder
- pka
- 13.73 · 13.73±0.10(Predicted)
- Farbe
- white to beige
- InChI
- InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
- InChIKey
- PDOQBOJDRPLBQU-QMMMGPOBSA-N
- SMILES
- C1(N[C@H](C2=NC=C(F)C=N2)C)=NC=C(Cl)C(NC2C=C(C)NN=2)=N1
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (75%): Toxic if swallowed [Danger Acute toxicity, oral]；H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]；H361 (75%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]；H372 (75%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
P203, P260, P264, P270, P280, P301+P316, P301+P317, P318, P319, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 4 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 3 (75%)；Acute Tox. 4 (25%)；Repr. 2 (75%)；STOT RE 1 (75%)
Sicherheitsdaten
- wgk
- WGK 3
- hs_code
- 29335990
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Chemie und Industrie
Anwendungen
VerwendenAZD1480 has been used as an inhibitor of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in an in vitro cell model of upper gastrointestinal adenocarcinoma. It has also been used in combination with bortezomib to study tumor-associated macrophage-mediated survival of myeloma cells.
Anbieter100 Anbieter
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
天津欣康佑生物科技有限公司19922659386 19922659386 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
苏州景皓生物科技有限公司18136139868; 18136139868 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
郑州格镭生物科技有限公司19903857099; 19937938981 · [email protected]
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