HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5,6,7,8-Tetrahydro-1-naphthylamin
1-NAPHTHALENAMINE, 5,6,7,8-TETRAHYDRO- · 5-Tetralylamine · 5-AMINOTETRALIN · Tetralin-5-amine · AKOS BBS-00003705 · 5-Tetralinylamine · TIMTEC-BB SBB004091 · 5,6,7,8-Tetrahydro-1
Identifikatoren & physikalische Daten
| CAS No. | 2217-41-6 |
|---|---|
| Summenformel | C10H13N |
| Durchschnittliche Molmasse | 147,22 g/mol |
| Monoisotopische Masse | 147,10479942 g/mol |
| SMILES | Nc1cccc2c1CCCC2 |
| InChIKey | SODWJACROGQSMM-UHFFFAOYSA-N |
| PubChem CID | 16671 |
| EC No. | 218-713-2 |
| DTXSID | DTXSID70176701 |
| Lokaler Name | 5,6,7,8-Tetrahydro-1-naphthylamin |
Chemische & physikalische Eigenschaften
| XLogP | 2,6 |
|---|---|
| Polarare Oberfläche (TPSA) | 26 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 11 |
| Formalladung | 0 |
| Komplexität | 133 |
| SpringerMaterials Properties | Viscosity |
| Schmelzpunkt | 38 °C(lit.) |
| Siedepunkt | 275-277 °C713 mm Hg(lit.) |
| Dichte | 1,06 g/cm3 |
| Brechungsindex | n20/D 1.590(lit.) |
| Flammpunkt | >230 °F |
| Löslichkeit | miscible with Alcohol |
| Aggregatzustand | Liquid |
| pKa (Säurekonstante) | 4.56±0.20(Predicted) |
| Farbe | Clear yellow to brown |
| BRN | 387264 |
| InChI | 1S/C10H13N/c11-10-7-3-5-8-4-1-2-6-9(8)10/h3,5,7H,1-2,4,6,11H2 |
| InChIKey | SODWJACROGQSMM-UHFFFAOYSA-N |
| SMILES | Nc1cccc2CCCCc12 |
| CAS Datenbank | 2217-41-6(CAS DataBase Reference) |
| NIST chemische Informationen | 1-Naphthalenamine, 5,6,7,8-tetrahydro-(2217-41-6) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: 1-Naphthalenamine, 5,6,7,8-tetrahydro-1-Naphthalenamine, 5,6,7,8-tetrahydro-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| F | 9 |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 29214990 |
| RTECS-Nr. | QM4780000 |
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36 |
| Lagerklasse | 10 - Combustible liquids |
Anwendungen & Verwendung
Verwenden
5,6,7,8-Tetrahydro-1-naphthylamine is used as a reagent in the synthesis of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. 5,6,7,8-Tetrahydro-1-naphthylamine is also used as a reagent in the synthesis of benzopyrans and related compounds as inhibitors of the hypoxia inducible factor pathway.