Bis(acetato)dibutylzinn

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.；STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Clothing contaminated with ... dibutyltin diacetate ... should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of contaminant from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the contaminant, the person performing the operation should be informed of contaminant's hazard properties. ... Non-impervious clothing which becomes contaminated with ... dibutyltin diacetate ... should be removed promptly & not reworn until the contaminant is removed.

Skin that becomes contaminated with ... dibutyltin diacetate ... should be promptly washed or showered with soap or mild detergent & water to remove any contaminant. ... Eating & smoking should not be permitted in areas where ... dibutyltin diacetate ... is handled, processed, or stored.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:；IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.；SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.；FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

0.1 [mg/m3], as Sn

0.2 [mg/m3], as Sn

8 hr Time Weighted Avg (TWA): 0.1 mg/cu m; 15 min Short Term Exposure Limit (STEL): 0.2 mg/cu m. Skin. /Tin, organic compounds, as Sn/

A4; Not classifiable as a human carcinogen. /Tin, organic compounds, as Sn/

0.009 [mg/m3]

1.1 [mg/m3]

6.3 [mg/m3]

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.；RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Employees should be provided with & required to use impervious clothing, gloves, face shields (8 inch minimum), & other appropriate protective clothing necessary to prevent repeated or prolonged skin contact with ... solid or liquid dibutyltin diacetate. ... Employees should be provided with & required to use dust- & splash-proof safety goggles where solid or liquid dibutyltin diacetate ... may contact the eyes.

Neurotoxin - Other CNS neurotoxin；Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.；ACGIH Carcinogen - Not Classifiable.

Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local release of pro-inflammatory cytokines, tumor necrosis factor-_, and/or interleukins. They may also induce apoptosis by direct action on neuronal cells. Organotin compounds stimulate the neuronal release of and/or decrease of neuronal cell uptake of neurotransmitters in brain tissue, including aspartate, GABA, glutamate, norepinephrine, and serotonin. This may be either a contributing factor to or result of the neuronal cell loss. The immunotoxic effects of organotins are characterized by thymic atrophy caused by the suppression of proliferation of immature thymocytes and apoptosis of mature thymocytes. Organotin compounds are believed to exert these effects by suppressing DNA and protein synthesis, inducing the expression of genes involved in apoptosis (such as nur77), and disrupting the regulation of intracellular calcium levels, giving rise to the uncontrolled production of reactive oxygen species, release of cytochrome c to the cytosol, and the proteolytic and nucleolytic cascade of apoptosis. The suppression of proliferation of immature thymocytes further results in the suppression of T-cell-mediated immune responses. Organotins are also endocrine disruptors and are believed to contribute to obesity by inappropriate receptor activation, leading to adipocyte differentiation. Inorganic tin triggers eryptosis, contributing to tin-induced anemia. (L308, A182, A184)

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=1067-33-0]

Dibutyltin diacetate

TR-183: Bioassay of Dibutyltin Diacetate for Possible Carcinogenicity (CASRN 1067-33-0) (1979 )

10/25/78

No Evidence

Inadequate Experiment

No Evidence

... THE EFFECT OF DIBUTYLTIN DIACETATE ON THE ULTRASTRUCTURE OF MOUSE LIVER /WAS STUDIED/. IN THIS STUDY, RATS WERE GIVEN ORALLY 1/4 LD50 DOSE /110 MG/KG/ DAILY FOR 10 DAYS. ONE RAT WAS SACRIFICED EACH DAY & THE LIVER TISSUE REMOVED FOR ... LIGHT & ELECTRON MICROSCOPY. WITHIN 2-3 DAY PERIOD, PATHOLOGIC FEATURES WERE OBSERVED, INDICATING THAT THE ... /CHEM/ WAS ACTING AS A HEPATOTOXIC AGENT. CHANGES IN THE ULTRASTRUCTURE OF LIVER CELLS WERE EVIDENT & EARLY MITOCHONDRIAL DAMAGE WAS OBSERVED. SWELLING OF GRANULAR & AGRANULAR ENDOPLASMIC RETICULUM FOLLOWED SOON AFTER THE MITOCHONDRIAL CHANGES WERE NOTED. PROGRESSIVE CONGESTION OF BILE CANALICULI OCCURRED, DUE IN PART TO CELLULAR & MICROVILLI SWELLING.

Dibutyltin diacetate was evaluated for the induction of sex-linked recessive lethal mutations in Drosophila melanogaster by the National Toxicology Program. Canton-S wild-type males were treated with concentrations of dibultyltin diacetate that result in approximately 30% mortality. Following treatment, males were mated individually to 3 harems of Basc virgin females to produce 3 broods for analysis. The concentrations of dibutyltin diacetate tested by injection (150 ppm) or feeding (15,000 and 20,000 ppm) were negative in this assay.

Dibutyltin diacetate was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by the National Toxicology Program. Dibutyltin diacetate was tested at doses of 0, 33, 100, 333, 1000, and 3333 ug/plate in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. Dibutyltin diacetate was negative in these tests and the highest ineffective dose level tested in any Salmonella tester strain was 3333 ug/plate.

... Under the conditions of this bioassay, there was no ... evidence of carcinogenicity for dibutyltin diacetate in male Fischer 344 rats or B6C3F1 mice of either sex. The loss of tissues taken from high dose female rats /reduced the sensitivity in this/ bioassay ... for female Fischer 344 rats. Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Inadequate Study; Male Mice: Negative; Female Mice: Negative.

A bioassay for the possible carcinogenicity of dibutyltin diacetate was conducted using Fischer 344 rats and B6C3F1 mice. Dibutyltin diacetate was admin in the feed, at either of two concn, to groups of 50 male and 50 female animals of each species. Twenty animals of each sex and species were placed on test as controls. The high and low time weighted avg dietary concn of dibutyltin diacetate were, respectively, 133 and 66.5 ppm for rats and 152 and 76 ppm for mice. The cmpd was admin for 78 wk to rats and mice, followed by a period of no cmpd admin of 26 wk for rats and 14 wk for mice. ... Under the conditions of this bioassay, there was no ... evidence of carcinogenicity for dibutyltin diacetate in male Fischer 344 rats or B6C3F1 mice of either sex. The loss of tissues taken from high dose female rats /reduced the sensitivity in this/ bioassay ... for female Fischer 344 rats. Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Inadequate Study; Male Mice: Negative; Female Mice: Negative.

LD50 Rat oral 32 mg/kg

LD50 Mouse oral 46 mg/kg

LD50 Mouse intravenous 18 mg/kg

LD50 MOUSE ORAL 109.7 MG/KG

Chemical: Stannane, bis(acetyloxy)dibutyl-

Hazard Traits - Reproductive Toxicity；Authoritative List - EC Annex VI CMRs - Cat. 1B；Report - if used as a fragrance or flavor ingredient

Acetic acid, 1,1'-(dibutylstannylene) ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, 1,1'-(dibutylstannylene) ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 30-06-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/13153

Dibutyltin diacetate: Does not have an individual approval but may be used under an appropriate group standard