3,6-Dichlor-o-anissure, Verbindung mit Dimethylamin (1:1)

Contain liquid spill with absorbent material, collect in a suitable waste container. Wash effected area with water and detergent. Keep wash water out of drains. Whenever possible, all product or absorbent material should be used/applied according to label instructions and quantities. Otherwise dispose of at an approved chemical waste facility.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:

Chemical-resistant footwear plus socks. Long-sleeved shirt and long pants. Protective eyewear. Waterproof gloves.

In oral, dermal, and inhaled routes of exposure, dicamba has a low acute toxicity. Dicamba may have irritating or corrosive effects on the skin and eyes. The EPA has identified dicamba as a developmental toxin in the Toxics Release Inventory. (L2156)

LD50 Anas platyrhynchos (Mallard duck, 20 weeks) oral >2510 mg/kg/14 days

LC50 Anas platyrhynchos (Mallard duck, 14 days old) dietary >4640 ppm/8 days

LD50 Anas platyrhynchos (Mallard duck, 6 months old) oral >2510 mg/kg/14 days

LC50 Colinus virginianus (Northern bobwhite, 14 days old) dietary >4640 ppm/8 days

For more Ecotoxicity Values (Complete) data for DIMETHYLAMINE DICAMBA (7 total), please visit the HSDB record page.

/AQUATIC SPECIES/ Chronic toxicity of the herbicide Banvel-D (dicamba; dimethylamine salt of 2-methoxy-3,6-dichlorobenzoic acid) was studied in Daphnia magna. ...Marked decrease of survival rate was recorded in variants with Banvel-D at 67 mg/L. Banvel-D at 67 mg/L also reduced fertility of Daphnia. Abnormal development was recorded in Daphnia exposed to Banvel-D at 11.5-45 mg/L (generation III and IV). Banvel-D at 23 and 45 mg/L resulted in deterioration of the physiological state, disturbances of embryogenesis and a decreased life span.

/SIGNS AND SYMPTOMS/ Dimethylamine salts of dicamba - loss of appetite, loss of weight, vomiting, depressions, general tenseness and muscular weakness.

/SIGNS AND SYMPTOMS/ Signs of dicamba intoxication include vomiting, bradycardia, shortness of breath, cyanosis, depression, incontinence, muscular weakness/exhaustion subsequent to muscle spasms (myotonia), and death. /Dicamba/

/LABORATORY ANIMALS: Acute Exposure/ Effect of banvel and dicamba (3,6-dichloro-o-anisic acid) was investigated employing rabbit mucous membrane irritancy test. Inflammatory changes which did not exceed an average score of 2+ were observed in the animals 48 hr after a single intravaginal application of banvel (0.1 mL/rabbit) and dicamba (100 mg/rabbit). Persistent histopathological changes were observed in 1 out of 6 banvel-treated rabbits 15 days post-application.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ /In a 90-day feeding study with rats/: NOEL=5000 ppm (250 mg/kg/day); LEL=10,000 ppm (500 mg/kg/day) (slight decrease in body weight and food consumption; reduction of cytoplasmic vacuolation of hepatocytes). /Banvel Technical/

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Technical Dicamba (86.8% pure) was fed in diet to Albino rats (60/sex/group) at 0, 50, 250 or 2500 ppm in the diet for 115 to 118 weeks. Chronic (Systemic) NOEL = 50 ppm (Brain ventricular dilatation associated with pituitary anterior adenomas were observed in females at > 250 ppm. Adrenal enlargement was increased at > 250 ppm in both sexes. Increased macroscopic lesions in liver at > 250 ppm (males) and lesions in lymph nodes at 2500 ppm (males) were observed.) Oncogenicity NOEL = 50 ppm (There were increased malignant lymphomas in females at > 250 ppm, increased parafollicular cell carcinoma, and adenoma, as well as increased follicular adenoma and carcinomas in treated males, primarily at 2500 ppm, but could be extended down to the lower doses.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Dicamba (purity =86.8%) was administered in the feed at concentrations of 0, 50, 150, 1000, or 3000 ppm/day to 52 CD-1 mice/sex/group. Males received dicamba treated diets for 89 weeks and females 104 weeks. Systemic NOEL = 50 ppm (Increased mortality at > 150 ppm was observed. Females at > 150 ppm showed decreased neutrophils and eosinophils and increased lymphocytes. Female kidney weights at > 1000 ppm were increased. Males showed enlarged spleens and pale kidneys at > 150 ppm. Females at > 150 ppm showed increased liver masses, enlarged spleen, kidney scarring and uterine distension.) Oncogenicity NOEL = 50 ppm (There was an increase in lymphoid leukemias and lymphoid sarcomas, in addition to hemangiosarcomas and hemangiomas at > 150 ppm). /Technical/

For more Non-Human Toxicity Excerpts (Complete) data for DIMETHYLAMINE DICAMBA (10 total), please visit the HSDB record page.

Skin contamination should be treated promptly by washing with soap and water. Contamination of the eyes should be treated immediately by prolonged flushing of the eyes with large amounts of clean water. If dermal or ocular irritation persists, medical attention should be obtained without delay. /Other Herbicides/

Ingestions of these herbicides are likely to be followed by vomiting and diarrhea due to the irritant properties. ... Activated charcoal is probably effective in limiting irritant effects and reducing absorption of most or all of these herbicides. Aluminum hydroxide antacids may be useful in neutralizing the irritant actions of mose acidic agents. Sorbitol should be given to induce catharsis if bowel sounds are present and if spontaneous diarrhea has not already commenced. Dehydration and electrolyte disturbances may be severe enough to require intravenous fluids. There are no specific antidotes for poisoning by these herbicides. /Other Herbicides/

If serious dehydration and electrolyte depletion have occurred as a result of vomiting and diarrhea, monitor blood electrolytes and and fluid balance and administer intravenous infusions of glucose, normal saline ringer's solution, or ringer's lactate to restore extracellular fluid volume and electrolytes. Follow this with oral nutrients as soon as fluids can be retained. Fluids serve to support excretion of the toxicants. Supportive measures are ordinarily sufficient for successful management of excessive exposures to these herbicides. /Other Herbicides/

LC50 (rat) >5,300 mg/m3;

oral LD50 in rats: 757 mg/kg body weight, dermal LD50 in rats: >2,000 mg/kg, inhalation LC50 in rats: >200 mg/L (L371)

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Dimethylamine dicamba is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0065; Pesticide type: herbicide; Registration Standard Date: 9/30/83 PB84-243492; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.; Active ingredient (AI): dimethylamine dicamba; Data Call-in (DCI) Date(s): 1/28/93, 3/3/95, 10/13/95; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner. /RED scheduled for 5/2006/