6,12'-Dimethoxy-2'-methyl-6',7-epoxyoxyacanthan

BeschreibungA bisbenzylisoquinoline alkaloid, this base has been isolated from Cocculus sarmentosus Diels and C. trilobus DC. It crystallizes as colourless prisms and is dextrorotatory with [α]29D + 296.3° (CHCI3). Both the hydrochloride and hydro_x0002_bromide are crystalline and sparingly soluble in H20 and the dimethiodide has m.p. 273°C (dec.). Two methoxyl groups and two methylimino groups are present. With dimethyl sulphate in NaOH, the base yields trilobinemethylmethine as long, colourless prisms, m.p. 106° C which is optically inactive and on ozonization furnishes 2-methoxy-5:4'-dialdehydodiphenyl ether, m.p. 72-5°C and a complex dialdehyde, m.p. 124°C.