2-Naphthoylethyltrimethylammonium
Grundinformationen
- CAS
31059-54-8- Standard-SMILES
C[N+](C)(C)CCC(=O)c1ccc2ccccc2c1.[I-]- InChIKey
LIFHUGCXEAQKRZ-UHFFFAOYSA-M- Summenformel
- C16H20INO
- Durchschnittliche Molmasse
- 369,24 g/mol
- Monoisotopische Masse
- 369,05896226
Überblick
structure given in first source; RN given refers to iodide
Namen und Bezeichner
- Bevorzugter Name
- 2-Naphthoylethyltrimethylammonium
- IUPAC
- trimethyl-(3-naphthalen-2-yl-3-oxopropyl)azanium iodide
- Englischer Name
- 2-naphthoylethyltrimethylammonium
- Summenformel
- C16H20NO.I
- Molmasse
- 369.24
Namen und Synonyme
31059-54-82-NaphthoylethyltrimethylammoniumRefChem:88641beta-NETAtrimethyl-(3-naphthalen-2-yl-3-oxopropyl)azanium;iodide-NETAbeta-NETA, 98%2-(beta-Naphthoyl)ethyltrimethylammonium iodideorb1308670SCHEMBL11253161DTXSID60953164AKOS040741094
Weitere Namen anzeigen
α-NETAβ-NETAβ-NETA, 10 mM in DMSOalpha-NETA, Fluorescent ChAT inhibitor2-Dimethylaminoethyl 2-naphthyl ketone methiodidetrimethyl-(3-naphthalen-2-yl-3-oxopropyl)azanium:iodidehistamine,Cholinesterase (ChE),Apoptosis,ChE,β-NETA,KCl,β NETA,ChA,choline acetyltransferase,βNETA,Inhibitor,cholinesterase,inhibit
MS-25926HY-124957CS-0089727T141942-Naphthalenepropanaminium, N,N,N-trimethyl-gamma-oxo-, iodide2-Naphthalenepropanaminium, N,N,N-trimethyl-|A-oxo-, iodide (1:1)N,N,N-trimethyl-3-(naphthalen-2-yl)-3-oxopropan-1-aminium iodide2-Naphthalenepropanaminium, N,N,N-trimethyl-gamma-oxo-, iodide (1:1)
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 17,1 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 19
- Formalladung
- 0
- Komplexität
- 292
Physikochemische Eigenschaften
- storage temp.
- -20 °C, · Store at -20°C, protect from light, stored under nitrogen
- Löslichkeit
- 3 mg/ml; · DMSO: 3mg/ml; Methanol: Soluble
- Aggregatzustand
- A solid
- Farbe
- White to off-white
Chemie und Industrie
Anwendungen
BeschreibungCholine acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture.
VerwendenCholine acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture.[Cayman Chemical]
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