Dexamethasone Sodium Phosphate
Grundinformationen
- CAS
2392-39-4- Standard-SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]- InChIKey
PLCQGRYPOISRTQ-FCJDYXGNSA-L- Summenformel
- C22H28FNa2O8P
- Durchschnittliche Molmasse
- 516,4 g/mol
- Monoisotopische Masse
- 516,13012127
Überblick
Dexamethasone sodium phosphate is an organic sodium salt which is the disodium salt of dexamethasone phosphate. It has a role as a glucocorticoid receptor agonist. It contains a dexamethasone phosphate(2-).
Namen und Bezeichner
- Bevorzugter Name
- Dexamethasone Sodium Phosphate
- IUPAC
- disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
- Englischer Name
- Dexamethasone 21-phosphate disodium salt
- Summenformel
- C22H28FNa2O8P
- Molmasse
- 516.4
Namen und Synonyme
DEXAMETHASONE SODIUM PHOSPHATE2392-39-4Dexamethasone 21-phosphate disodium saltDalaloneDexadresonMegacortSoldesamDexamethasone disodium phosphateDecadron phosphateDexabeneAk-DexDexair
Weitere Namen anzeigen
decadronphosphateDEXAMETHASON SODIUM PHOSPHATEDEXAMETHASONE PHOSPHATE SODIUMDexamethasone sodium phosphate for peak identification1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALTBaldexDecdandexagroDexagel
Sodium dexamethasone phosphateDexacen-4DTXSID3047429MEPHAMESONESOLUDECADRONTOTOCORTINTLC399SOLUPEN N
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 147 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 9
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 34
- Formalladung
- 0
- Komplexität
- 961
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsActive Ingredients (Dexamethasone Sodium Phosphate) -> FDA Greenbook
Collision Cross Section200.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 233 · 233-235 °C
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 2 O: · H2O: 50 mg/mL, clear, faintly yellow
- Aggregatzustand
- White Powder
- Farbe
- white to off-white
- PH
- 10 g/l, · pH(10g/l, 25℃) : 7.5～10.5
- Wasserlöslichkeit
- Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
- Merck
- 13 · 13,2960
- BRN
- 6473066 · 6473066
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H302 (93.9%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P264, P270, P280, P301+P317, P318, P319, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 132 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Status: Active Update: 07-02-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21119
Dexamethasone sodium phosphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.alpha.)-: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (93.9%)
Sicherheitsdaten
- F
- 3-10
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 2937220000
- RTECS-Nr.
- TU4056000
- risk_code
- 22-40-63
- hazard_code
- Xn
- safety_code
- 36/37/39
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
DEXAMETHASONE SODIUM PHOSPHATE
Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]
MeSH Pharmacological Classification
Substances that reduce or suppress INFLAMMATION.
Drugs used to prevent NAUSEA or VOMITING.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
Verwendung und Herstellung
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
General Manufacturing InformationPregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, sodium salt (1:2), (11.beta.,16.alpha.)-: ACTIVE
Anwendungen
Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.
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