Turletricin
Grundinformationen
- CAS
2761794-74-3- Standard-SMILES
C[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N)[C@H]2O)C[C@@H]2O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@H]1C)C[C@H](O)[C@H]2C(=O)NC(CO)CO- InChIKey
DYFDQVUOYRWTOB-JYUTVPRCSA-N- Summenformel
- C50H80N2O18
- Durchschnittliche Molmasse
- 997,2 g/mol
- Monoisotopische Masse
- 996,54061371
Überblick
Turletricin is a structurally modified derivative of the polyene antifungal antibiotic amphotericin B, with potential antifungal activity, especially against certain antifungal-resistant and/or invasive fungal pathogens such as Aspergillus, Candida and Cryptococcus species. Upon intravenous administration, turletricin froms extramembraneous sponge-like aggregates which bind to ergosterol, an essential component of the fungal cell membrane. By binding to ergosterol from fungal cell membranes, turletricin alters cell membrane integrity, resulting in leakage of intracellular components and cell rupture, and causing fungal cell death. EL219 is designed to enhance ergosterol selectivity over mammalian cholesterol and reduce amphotericin B-mediated nephrotoxicity.
Namen und Bezeichner
- Bevorzugter Name
- Turletricin
- IUPAC
- (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-N-(1,3-dihydroxypropan-2-yl)-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxamide
Namen und Synonyme
TurletricinAM-2-192761794-74-3turletricin [INN]TDF5DY3ZVYAM-2-19 free baseTURLETRICIN [USAN]Sfu-AM2-19SCHEMBL26741761EL219SF001 (AM-2-19)HY-161091
Weitere Namen anzeigen
CS-0926500(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-(((2R,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-N-(1,3-dihydroxypropan-2-yl)-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxamide(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-N-(1,3-dihydroxypropan-2-yl)-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxamideAmphotericin B, 19-O-(3-amino-3,6-dideoxy-beta-D-glucopyranosyl)-19-O-de(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)-16-decarboxy-16-[[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]carbonyl]-
Datenbank-Bezeichner
- CAS
2761794-74-3- PubChem CID
- 170453316
- UNII
- TDF5DY3ZVY
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 0,7
- Polarare Oberfläche (TPSA)
- 352 Ų
- H-Brücken-Donoren
- 14
- H-Brücken-Akzeptoren
- 19
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 70
- Formalladung
- 0
- Komplexität
- 1.770
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…