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HCID 17596Erstellt: 4. November 2026

Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocin

OCTAHYDRO-1,3,5,7-TETRANITRO-1,3,5,7-TETRAZOCINE · OCTOGEN · hw4 · HMX · HW 4 · lx14-0 · LX 14-0 · Oktogen

https://huagongshe.com/de/chemical/17596

Molekülstruktur von Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocin

Identifikatoren & physikalische Daten

CAS No.2691-41-0
SummenformelC4H8N8O8
Durchschnittliche Molmasse296,16 g/mol
Monoisotopische Masse296,04650924 g/mol
SMILESO=[N+]([O-])N1CN([N+](=O)[O-])CN([N+](=O)[O-])CN([N+](=O)[O-])C1
InChIKeyUZGLIIJVICEWHF-UHFFFAOYSA-N
PubChem CID17596
ChEBICHEBI:33176
EC No.220-260-0
DTXSIDDTXSID3024237
Lokaler NameOctahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocin

Chemische & physikalische Eigenschaften

XLogP2,1
Polarare Oberfläche (TPSA)196
H-Brücken-Donoren0
H-Brücken-Akzeptoren12
Frei drehbare Bindungen0
Schwere Atome20
Formalladung0
Komplexität322
StoffklassenOther Uses -> ExplosivesFlammable agents - 4th degree
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
PestizidePesticide -> EPA IRIS
LogP (Verteilungskoeffizient)log Kow = 0.160.17
DichteDensity of the four polymeric forms: 1.903 g/cu cm (beta form)1.82 g/cu cm (alpha form)1.82 g/cu cm (gamma form)1.78 g/cu cm (delta form)Detonation velocity = 9100 m/s at max densityExplosion temperature after 5 seconds = 330 °C1.9 g/cm³Density (g/cm3): b=1.903a=1.87g=1.82d=1.78
Color/FormWhite crystalline solid
LöslichkeitIn water, 3.34 mg/L at 20 °C, 4.46 mg/L at 25 °CIn water, 5 mg/L at 25 °CSolubility in water = 1.40X10+2 mg/L at 83 °CSolubility in water: none4.46mg/L at 25℃
SiedepunktDecomposition temperature = 280 °C536 °F (decomposes)437.77°C (rough estimate)
DecompositionDecomposes violently at 279 °C.When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
SchmelzpunktMelting point equals 281 °C. [CAMEO]275 °C537.8 °F279 °C281°
Dampfdichte1.9
Dampfdruck0.00000002 [mmHg]VP: 3.3X10-14 mm Hg at 25 °CVapor pressure, Pa at 25 °C:2.41x10-8 mmHg0Pa at 25℃
Brechungsindex1.6910 (estimate)
Flammpunkt2℃
Lagerbedingungen2-8°C
pKa (Säurekonstante)-16.32±0.20(Predicted)
AggregatzustandColorless solid
Spezifische WärmekapazitätCp(gas): 0.93 J/(g·K), at 25℃
Henry-Konstante1.1×104 mol/(m3Pa) at 25℃, HSDB (2015)
LogP (Verteilungskoeffizient)0.165 at 21℃
CAS Datenbank2691-41-0
EPA chemische InformationenCyclotetramethylenetetranitramine (2691-41-0)

Sicherheit & Vorschriften

GHS-EinstufungThis chemical does not meet GHS hazard criteria for 2.9% (3 of 104) of reports.DangerH201 (77.9%): (Deleted) Explosivemass explosion hazard [Danger Explosives]P210, P230, P234, P236, P240, P250, P262, P264, P270, P280, P301+P317, P302+P352, P316, P321, P330, P361+P364, P370+P380, P370+P380+P375, P372, P373, P401, P405, P501, and P503 (click each P-code to see the statement)Aggregated GHS information provided per 104 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatorische InformationenChemical: 1,3,5,7-Tetrazocine, octahydro-1,3,5,7-tetranitro-Hazard Traits - Hepatotoxicity and Digestive System ToxicityNeurotoxicity1,3,5,7-Tetrazocine, octahydro-1,3,5,7-tetranitro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3,5,7-Tetrazocine, octahydro-1,3,5,7-tetranitro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)REACH registered substance: Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (EC: 220-260-0)1,3,5,7-Tetrazocine, octahydro-1,3,5,7-tetranitro-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
DOT-KennzeichnungExplosive 1.1D
BrandgefahrenExcerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion. Explosive.
GesundheitsgefahrenExcerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:
GefahrenübersichtHMX (Octogen) is an acronym for High Melting eXplosive. It is also known as octogen and cyclotetramethylene-tetranitramine, as well as by other names. It is a colorless solid that dissolves slightly in water. Only a small amount of HMX (Octogen) will evaporate into the air

Anwendungen & Verwendung

Verwenden

HMX has uses similar to RDX, that is, as a base charge for detonators and as an ingredient of bursting-charge and plastic explosives by the military.

however, it can occur in air attached to suspended particles or dust. The taste and smell of HMX (Octogen) are not known. HMX (Octogen) does not occur naturally in the environment. It is made from other chemicals known as hexamine, ammonium nitrate, nitric acid, and acetic acid. HMX (Octogen) explodes violently at high temperatures. Because of this property, HMX (Octogen) is used in various kinds of explosives, rocket fuels, and burster chargers. A small amount of HMX (Octogen) is also formed in making cyclotrimethylene-trinitramine (RDX), another explosive similar in structure to HMX (Octogen).
Studies of munition plant workers have been negative for adverse effects. In high-dose animal studies, injury to the kidneys, liver, and CNS is observed. Rats survive exposures up to 4,000 mg/kg/day for 13 weeks. [HSDB] Emits nitrogen oxides when heated to decomposition
Explodes at 279 degrees C
Toxic by ingestion
[Sax] Highly explosive! [Merck Index, 6758]
Reaktive GruppeAzo, Diazo, Azido, Hydrazine, and Azide Compounds
UN-EinstufungUN Hazard Class: 1.1DUN Pack Group: II
TSCA-AnforderungenSection 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date: September 29, 2006Reporting date: November 28, 2006.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1,3,5,7-Tetrazocine, octahydro-1,3,5,7-tetranitro- is included on this list. Effective date: September 29, 2006Sunset date: November 28, 2006.
Reactivity AlertsExplosive
Reactivity ProfileCYCLOTETRAMETHYLENE TETRANITRAMINE, [WET WITH >= 10% WATER] is a high explosive. May begin a vigorous reaction that culminates in a detonation if mixed with reducing agents, including hydrides, sulfides and nitrides. May explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water. Presence of metal oxides increases thermal sensitivity. Wetting reduces sensitivity toward detonation.
Chemical DangersHeating may cause violent combustion or explosion. May decompose explosively on shock, friction or concussion. Decomposes on heating. This produces toxic gases including nitrogen oxides. Reacts violently with acids and bases.
Physical DangersAs a result of flow, agitation, etc., electrostatic charges can be generated. Dust explosion possible if in powder or granular form, mixed with air.
BrandbekämpfungExcerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:In case of fire in the surroundings, use appropriate extinguishing media. Combat fire from a sheltered position.
Erste-Hilfe-MaßnahmenFresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer for medical attention .
Erste HilfeExcerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:
Sichere LagerungFireproof. Separated from strong bases and strong acids. Store in an area without drain or sewer access.
Firefighting HazardsMay explode and throw fragments 1600 meters (1 mile) or more if fire reaches cargo.[CAMEO Chemicals/NOAA Chemical Datasheet on Cyclotetramethylene tetranitramine,
BrandbekämpfungsverfahrenCargo fire: Do not fight fire when fire reaches cargo! Cargo may explode! Stop all traffic and clear the area for at least 1600 meters (1 mile) in all directions and let burn. Do not move cargo or vehicle if cargo has been exposed to heat. Tire or vehicle fire: Use plenty of water - flood it! If water is not available, use CO2, dry chemical or dirt. If possible, and without risk, use unmanned hose holders or monitor nozzles from maximum distance to prevent fire from spreading to cargo area. Pay special attention to tire fires as re-ignition may occur. Stand by, at a safe distance, with extinguisher ready for possible re-ignition.[CAMEO Chemicals/NOAA Chemical Datasheet on Cyclotetramethylene tetranitramine,
ReinigungsverfahrenIsolate spill or leak area immediately for at least 500 meters (1/3 mile) in all directions. Large spill: Consider initial evacuation for 800 meters (1/2 mile) in all directions. Fire: If rail car or trailer is involved in a fire, isolate for 1600 meters (1 mile) in all directionsalso, initiate evacuation including emergency responders for 1600 meters (1 mile) in all directions.[CAMEO Chemicals/NOAA Chemical Datasheet on Cyclotetramethylene tetranitramine,Eliminate all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Do not operate radio transmitters within 100 meters (330 feet) of electric detonators. Do not clean-up or dispose of, except under supervision of a specialist.[CAMEO Chemicals/NOAA Chemical Datasheet on Cyclotetramethylene tetranitramine,
Freisetung ohne BrandExcerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:
EntsorgungsverfahrenSRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Batch carbon adsorption studies were conducted for pollutants (TNT, RDX, TAX, HMX, & SEX) from Holston AAP industrial liquid waste treatment facility.Ultraviolet radiation and hydrogen peroxide studies were conducted for pollutants: TNT, RDX, HMX, and SEX from Holston Army Ammunition Plant liquid waste treatment facility.Pilot studies were conducted on each of the streams from army ammunition plants and simulated stream for a new facility being considered for production of RDX/HMX. Both the activated sludge system and rotating biological contactor system show a high degree of BOD removal. In both systems carbon columns are needed to remove the nonbiodegradable contaminates from the streams. An optimum treatment approach may be a hybrid system.For more Disposal Methods (Complete) data for Cyclotetramethylenetetranitramine (6 total), please visit the HSDB record page.
Verschüttetes entsorgenEvacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: chemical protection suit. Cover the spilled material with water. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Do NOT let this chemical enter the environment.
Isolation and EvacuationExcerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:
Eye PreventionWear safety spectacles or eye protection in combination with breathing protection if powder.
Toxikologische InformationenCDC-ATSDR Toxicological Profile
ZielorganeHepatic (Liver), Neurological (Nervous System)
ÖkotoxizitätswerteLC50Species: Pimephales promelas (Fathead minnow) 7-day old fryConditions: freshwater, static, 25 °C, pH 7.1, hardness 35 mg/L CaCO3Concentration: 15 mg/L for 96 hr (95% confidence interval: 8.8-26 mg/L) /formulated product/Species: Oncorhynchus mykiss (Rainbow trout) weight 0.9 g, length 43 mmConditions: freshwater, static, 10 °C, pH 7.1, hardness 35 mg/L CaCO3, dissolved oxygen 4.0-9.0 mg/LConcentration: >32 mg/L for 24, 48, 96 hr /formulated product/Species: Ictalurus punctatus (Channel catfish) weight 1.2 g, length 57 mmConditions: freshwater, static, 20 °C, pH 7.1, hardness 35 mg/L CaCO3, dissolved oxygen 4.0-9.0 mg/LSpecies: Lepomis macrochirus (Bluegill) weight 1 g, length 35 mmFor more Ecotoxicity Values (Complete) data for Cyclotetramethylenetetranitramine (8 total), please visit the HSDB record page.
UmweltverhaltenTERRESTRIAL FATE: Based on a classification scheme(1), measured Koc values of 30-290(2), indicate that cyclotetramethylenetetranitramine is expected to have very high to moderate mobility in soil(SRC). Volatilization of cyclotetramethylenetetranitramine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.7X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Cyclotetramethylenetetranitramine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.4X10-8 mm Hg at 25 °C(SRC), determined from a fragment constant method(3). Cyclotetramethylenetetranitramine is not expected to degrade aerobically in soil based on 0% degradation in both fortified and field contaminated soil samples after 56 days(4). However, anaerobic biodegradation of this compound is expected based on 90% degradation after 10 days in tests using an anaerobic sewage sludge innoculum and 100% degradation after 11 days, 100% after 20-22 days, 77% after 28 days in tests using anaerobic sewage sludge enrichment cultures(5,6).AQUATIC FATE: Based on a classification scheme(1), measured Koc values of 30 and 290 in soil(2) and 670 in sediment(3), indicate that cyclotetramethylenetetranitramine may adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 8.7X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are both much greater than 1 year(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow of 0.17(7) and a regression-derived equation(5), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The hydrolysis half-life of cyclotetramethylenetetranitramine has been measured to be 21 years in an aqueous acetone solution at pH 8 and 15 °C(3). Cyclotetramethylenetetranitramine was stable over a period of 70 days in fortified reagent-grade water, ground water, and surface water samples at initial concentrations of 45.97 ug/L, 68.50 ug/L, and 47.53 ug/L, respectively(8). Cyclotetramethylenetetranitramine is not expected to biodegrade aerobically in water based on 0% degradation after 28 days using a sludge enrichment culture from a sewage treatment plant(9). However, this substance has been shown to biodegrade slowly in an anaerobic river water sample with 50% biodegradation achieved after 50 days(10).AQUATIC FATE: The impact of photolysis and biotransformation on the persistence of HMX in water from the Holston River near the Holston Army Ammunition Plant (HAAP), Kingsport, TN and Louisiana Atmy Ammunition Plant (LAAP) lagoons, Minden, LA was reported. Photolysis was found to be the dominant transformation process in the Holston River. Poor light transmission through the lagoon waters inhibited photolytic processes. Conditions were not favorable for biotransformation in the Holston River or in LAAP lagoons. Computer simulations of the Holston River and LAAP lagoons indicate that HMX will be persistent in these environments with dilution serving as the major factor in reducing HMX concentrations in these bodies of water(1).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cyclotetramethylenetetranitramine, which has an estimated vapor pressure of of 2.4X10-8 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase cyclotetramethylenetetranitramine may be removed from the air by wet and dry deposition(SRC). Photolysis is expected to be an important fate process for cyclotetramethylenetetranitramine in sunlit environments based on photolysis half-lives of 1.4 days in pure water and 1.7 days in river water(3).
ExpositionspfadeThe substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.
ToxizitätsübersichtIDENTIFICATION AND USE: Cyclotetramethylenetetranitramine (HMX) is a white crystalline solid. HMX has uses similar to RDX, that is, as a base charge for detonators and as an ingredient of bursting-charge and plastic explosives by the military. HUMAN STUDIES: Human exposure of munitions plant workers has indicated no adverse effects. However, a 28-year-old man with no history of epilepsy was admitted to the Emergency Department for seizures that had developed during the night after a full working day when he manually sieved large amounts of dry HMX. ANIMAL STUDIES: Following exposure to a single oral dose of 5,447, 1,626, and 50 mg/kg HMX in rats, mice, and rabbits, respectively, a "reddening" of the lungs was observed. A "white fluid" was noted in the gastrointestinal tract of rats and mice exposed to a single oral dose of 5,447 and 1,626 mg/kg HMX, respectively. Deaths in rabbits were observed following single oral doses of 100 mg/kg or more. In mice, the males appeared to be more sensitive to the lethal effects of HMX. In rats, HMX may adversely affect the kidney. Hepatocyte hyperplasia and cytoplasmic eosinophilia were noted in rats and mice exposed to 1,280 and 300 mg/kg/day HMX, respectively, for 14 days. Clear evidence of hepatotoxicity was observed at a higher dose of 8,504 mg/kg/day HMX, which resulted in centrilobular degeneration in male rats exposed for 14 days. Based on the results of 13 weeks dietary study in rats, a NOAEL of 50 mg/kg/day for males and 115 mg/kg/day for females was estimated, together with a LOAEL of 150 mg/kg/day for toxic liver effects in males and 270 mg/kg/day for toxic renal effects in females. Fourteen day studies in mice showed increased activity and excitability at 100 mg/kg/day. Studies in animals have reported neurological effects following acute oral, dermal, and parenteral exposures to HMX. HMX did not exhibit mutagenic activity in Salmonella typhimurium using the Ames test. ECOTOXICITY STUDIES: Environmental studies suggest that the potential for reproductive toxicity of HMX to birds is low. Freshwater invertebrates exposed to explosives at contaminated sites may be affected at concentrations less than 25 mg/kg through hormetic growth enhancement and at higher concentrations through increased mortality. Generally, no adverse effects of exposure to 32 mg HMX/L were observed among any of the algae, fish, or invertebrate species tested. The 7-day old fry of fathead minnow were the only life stage or species acutely affected. Although RDX and HMX did not have adverse effects on plants, these compounds did cause earthworm mortality. Synergistic effects of explosives mixture were observed.
Ökotoxizitätsauszüge/BIRDS and MAMMALS/ High-melting explosive (HMXoctahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine) is a widely utilized explosive component of munitions used by the military. Consequently, production and use through testing and training at military installations has resulted in deposition of HMX in soil. Since these areas are often used by birds, the oral toxicity of HMX exposure to northern bobwhite (Colinus virginianus) was evaluated. Attempts to determine the acute lethal dose were unsuccessful. Initially, 8 birds (1 male/1 female per dose group) were orally dosed at levels ranging from 125 to 2125 mg HMX/kg body weight. A single death at the midrange resulted in subsequent trials of oral doses up to 10,760 mg/kg body weight. Only a single death occurred at 7173 mg/kg. A subsequent 28-day feeding study was then conducted to evaluate the potential for toxicity resulting from repetitive oral exposures. Northern bobwhite were exposed to concentrations of HMX in feed of either 10000, 1000, 100, or 0 mg/kg. These exposures resulted in a clear concentration-related reduction in feed consumption and body mass. Reductions in egg production in females were correlated with changes in body mass and feed consumption. Other physiological indicators were consistent with a considerable reduction in feed intake. These results suggest that HMX concentration is responsible for intense feed aversion behavior and thus not likely a factor that would appreciably contribute to risk for wild birds at military ranges./BIRDS and MAMMALS/ Adult Northern bobwhite quail (Colinus virginianus) were exposed via food to octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), an energetic compound found in soils at military training installations. Depuration of HMX into eggs was examined in an initial study, and effects on egg production, hatching, growth, development, and survival of chicks were examined in a follow-up study. HMX was readily and rapidly transferred from female quail into eggs. Marked weight loss was observed in quail exposed to 125 and 250 mg/kg HMX in food, likely due to reductions in food intake rather than a toxic mechanism. In the second study, significant alterations in body mass occurred among quail at concentrations >52.5 +/- 9.3 mg/kg but not at 12.3 +/- 1.1 mg/kg in food. Treatment-related reductions in food consumption and decreases in egg laying rates were observed. No HMX-related effects were found in chick growth or survival. Quail inhabiting HMX-contaminated sites could possibly be exposed to HMX and therefore deposition of HMX into eggs is also possible. However, results of these studies further suggest that the potential for reproductive toxicity of HMX to birds is low./BIRDS and MAMMALS/ ...Northern bobwhite quail (Colinus virginianus) were exposed to octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) via feed containing nominal concentrations of 0, 12.5, 50.0, and 125.0 mg/kg. Metabolic rates (oxygen consumption) of developing quail eggs were then measured via respirometry to examine potential effects of HMX exposure. Metabolic rates were examined on 5, 9, and 21 days of incubation. Next, concentrations of HMX in embryos/eggs were determined by liquid chromatography-mass spectrometry. Mean (+/- SE) concentrations of HMX in eggs were 21.0 +/- 5.9, 1113 +/- 79.0, 3864 +/- 154.0, and 7426 +/- 301.1 ng/g in control, low, medium and high dose groups, respectively. There were significant differences in oxygen consumption among the three embryo ages, however differences among the ages were not consistent among dose groups (age x dose group interaction p<0.0001). Oxygen consumption rates did not vary as a function of HMX in embryos (p=0.18). No evidence was observed for alterations of in ovo metabolic rates associated with HMX exposure./AQUATIC SPECIES/ Lethal and sublethal effects of the explosive compounds, 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) were assessed in separate water only exposures to the Mediterranean mussel (Mytilus galloprovincialis). Toxicity endpoints included survival and byssal thread formation in adults, and larval development success of embryos, in 96- and 48-hr exposures, respectively. The larval development endpoint was over an order of magnitude more sensitive to TNT compared to adult survival, with median effective concentration (EC50) values of 0.75 and 19.5 mg/L (3.30 and 74.1 umol/L), respectively. Byssal thread formation (48 hr EC50=6.57 mg/L29.3 umol/L) was also impaired at sublethal concentrations. The highest RDX and HMX concentrations tested (28.4 and 1.9 mg/L [124 and 6.43 umol/L], respectively) failed to promote any significant toxicological effect in exposed mussels. Median lethal residues (LR50) of 14.0 ug/g (51.0 nmol/g) ww for TNT in the adults were similar to those measured for other marine invertebrates in previous studies, while body residues as high as 19.6 and 0.92 ug/g (86 and 3.1 nmol/g) ww were not associated with any toxicity for RDX and HMX, respectively.For more Ecotoxicity Excerpts (Complete) data for Cyclotetramethylenetetranitramine (10 total), please visit the HSDB record page.
Plant ConcentrationsThe concentration of cyclotetramethylenetetranitramine in plants grown in soil contaminated with this explosive (8.6 mg/kg) was 43 mg/kg in lettuce, 4.3 mg/kg in corn stover, and 6.0 mg/kg in yellow nutsedge(1). This substance was not detected in tomatoes and corn kernels grown in this soil. The concentrations of cyclotetramethylenetetranitramine in the agricultural crops Medicago sativa, Phaseolus vulgaris, Brasica rapa, Lolium perenne, and Triticum aestivum grown in contaminated soil were 1.915 mg/pot, 1.807 mg/pot, 4.69 mg/pot, 7.199 mg/pot, and 4.383 mg/pot at soil concentrations of 100.9 mg/pot, 85.0 mg/pot, 90.5 mg/pot, 88.7 mg/pot, and 88.9 mg/pot, respectively(2). Cyclotetramethylenetetranitramine has been detected, but not quantified, in the blade tissue of rye grass grown in soil contaminated with 0.10 mM of this explosive(3).
Signs and SymptomsSee Ingestion.MAY BE ABSORBED! Redness.Redness. Pain.Confusion. Drowsiness. Convulsions. Unconsciousness.
Effluent ConcentrationsCyclotetramethylenetetranitramine has been identified in munition wastes from several army ammunition plants at concentrations of 289 ug/L in wastewater from a load and pack operation following activated carbon treatment, 1652 ug/L in water from an old lagoon once used for disposal of load and pack wastewater prior to use of the carbon treatment process, and below the detection limit (26 ug/L) in groundwater from a contaminated water supply, sample dates were not provided(1)concentrations in wastewater from a melt and pour operation for artillery shell loading were 4600 ug/L before any carbon columns, 606 ug/L after one carbon column, and below the detection limit after two carbon columns(1). Cyclotetramethylenetetranitramine was detected at concentrations ranging from not detected to 4.4 mg/L in grab samples from the Arnott Branch of the Holston River downstream from the Holston Army Ammunition Plant sampled in Jan-June 1973cyclotetramethylenetetranitramine was detected at concentrations of not detected to 7.5 mg/L in process waste from this facility(2). In another study, concentrations of cyclotetramethylenetetranitramine in Holston River waste stream samples ranged from 0.6-2.7 ppm(3).Studies were conducted for pollutants (TNT, RDX, TAX, HMX, and SEX) from Holston AAP industial liquid waste treatment facility.
ICSC Environmental DataThis substance may be hazardous to the environment. Special attention should be given to aquatic organisms.
EPA IRIS InformationOctahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)Hepatic5 x 10 ^-2 mg/kg-day
DHS Chemicals of Interest (COI)HMXA Commercial Grade5,000400Explosive chemical that can be released at a facility.
Landesrichtlinien für Trinkwasser(ME) MAINE 350 ug/L
Bundesrichtlinien für TrinkwasserEPA 400 ug/L
Wassergefährdungsklasse (WGK)2
TSCA-Inventar-StatusTSCA listed
UN-TransportnummerUN 0484 1.1D (CYCLOTETRAMETHYLENE- TETRANITRAMINE (HMXOCTOGEN), DESENSITIZED)
Zollcode29339900
R-Sätze (R)11-23/24/25-36/37/38-36-20/21/22-3
ToxizitätLD50 oral in rabbit: 50mg/kg
GefahrensymboleF,T,Xn,E
Sicherheitshinweise (S)16-27-45-36/37-35-26
Gefahrenklasse1.1D
Gefahrstoffdaten2691-41-0(Hazardous Substances Data)