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Sulfuryldifluorid
SO2F2 · Sulfonyl fluoride · sulfuryl · Sulfuryl difluoride · Vikane · sulfuryldifluoride · Vulkane · Vikane[R]
Identifikatoren & physikalische Daten
| CAS No. | 2699-79-8 |
|---|---|
| Summenformel | F2O2S |
| Durchschnittliche Molmasse | 102,06 g/mol |
| Monoisotopische Masse | 101,95870674 g/mol |
| SMILES | O=S(=O)(F)F |
| InChIKey | OBTWBSRJZRCYQV-UHFFFAOYSA-N |
| PubChem CID | 17607 |
| ChEBI | CHEBI:39287 |
| EC No. | 220-281-5 |
| DTXSID | DTXSID9034945 |
| Lokaler Name | Sulfuryldifluorid |
Chemische & physikalische Eigenschaften
| XLogP | 0,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 42,5 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 5 |
| Formalladung | 0 |
| Komplexität | 85 |
| Geruch | Odorless |
| Dichte | 3.72 G/L (GAS), 1.7 G/L (LIQ)Density = 4.172 g/L1.7 @ -55°C3.72(relative gas density)gas: 4.55g/L1.7 [CRC10] |
| Color/Form | Colorless gas [Note: shipped as a liquified compressed gas] |
| Löslichkeit | 0.2 % at 32 °F (NIOSH, 2024)4-5 ml gas/100 ml water24-27 ml gas/100 ml alc136-138 ml gas/100 ml carbon tetrachloride210-220 ml gas/100 ml tolueneSLIGHTLY SOL IN ALKALISMISCIBLE WITH METHYL BROMIDESPARINGLY SOL IN MOST ORG SOLVENTSIn ethanol 0.24 to 0.27 L/Lin toluene 2.1 to 2.2 L/Lin carbon tetrachloride 1.36 to I.38 L/LFor more Solubility (Complete) data for SULFURYL FLUORIDE (6 total), please visit the HSDB record page.slightly soluble in H2O, ethanolsoluble in toluene,ctcmL SO2F2/100mL solvent: 4–5, H2O24–27, alcohol210–220, toluene136–138, CCl4, [MER06] |
| Corrosivity | NON-CORROSIVE |
| Siedepunkt | -68 °F at 760 mmHg (NIOSH, 2024)-55.38 °C-55.3 °C-55 °C @760 [mm Hg]-55,2°C |
| Decomposition | When heated to decomposition it emits toxic fumes of /sulfur oxides and hydrogen fluoride/. |
| Schmelzpunkt | -212 °F (NIOSH, 2024)-135.82 °C-135.8 °C-137 °C-121,4°C |
| Dampfdichte | 3.72 (NIOSH, 2024) - Heavier than airwill sink (Relative to Air)3.5 (Air= 1)Relative vapor density (air = 1): 3.5 |
| Dampfdruck | 15.8 atm at 70 °F (NIOSH, 2024)Vapor pressure = 9150 mm Hg at 50 °F (10 °C)1.7X10+6 Pa at 21 °C (12.8 mm Hg at 21.1 °C)Vapor pressure, kPa at 21.1 °C: 170015.8 atm at 70 °F12000 [mm Hg] @21 °C |
| Ionization Potential | 13.04 eV |
| Physical Description | Sulfuryl fluoride appears as a colorless odorless gas. Shipped as a liquefied gas under its own vapor pressure. Noncombustible. Heavier than air. Very toxic by inhalation. Contact with the unconfined liquid can cause frostbite. Prolonged exposure to heat can cause containers to rupture violently and rocket. Used as an insecticide fumigant in wooden structures to control termites and wood-infesting beetles, and used in organic synthesis.Colorless, odorless gas. [insecticide/fumigant] [Note: Shipped as a liquefied compressed gas.] [NIOSH]COLOURLESS ODOURLESS COMPRESSED OR LIQUEFIED GAS.Colorless, odorless gas.Colorless, odorless gas. [insecticide/fumigant] [Note: Shipped as a liquefied compressed gas.] |
| Aggregatzustand | colorless gas |
| Farbe | colorless |
| Spezifische Wärmekapazität | Cp(gas): 0.65 J/(g·K), at 25℃ |
| Henry-Konstante | 8.9×10-5 mol/(m3Pa) at 25℃, Cady and Misra (1974) |
| Stabilität | Stable. Reacts with water. |
| InChI | InChI=1S/F2O2S/c1-5(2,3)4 |
| InChIKey | OBTWBSRJZRCYQV-UHFFFAOYSA-N |
| SMILES | S(F)(F)(=O)=O |
| CAS Datenbank | 2699-79-8(CAS DataBase Reference) |
| EPA chemische Informationen | Sulfuryl fluoride (2699-79-8) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH331: Toxic if inhaled [Danger Acute toxicity, inhalation]H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]P260, P261, P271, P273, P304+P340, P316, P319, P321, P391, P403+P233, P405, and P501 (click each P-code to see the statement) |
|---|---|
| Hazards Identification | Toxic/poison by inhalation (TIH/PIH) |
| Regulatorische Informationen | Regulation (EC) No 396/2005 (amended)Sulfuryl fluoride is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)2010/38/EU, Reg. (EU) 2017/270, Reg. (EU) 2018/184, Reg. (EU) 2023/1757, Reg. (EU) 540/2011Sulphuryl fluoride: HSNO Approval: HSR001381 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| DOT-Kennzeichnung | Poison Gas |
| Brandgefahren | Excerpt from ERG Guide 123 [Gases - Toxic]:Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket. (ERG, 2024)· Some may burn but none ignite readily.· Vapors from liquefied gas are initially heavier than air and spread along ground.· Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices.· Containers may explode when heated.· Ruptured cylinders may rocket.Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Brandpotenzial | Noncombustible |
| Gesundheitsgefahren | Excerpt from ERG Guide 123 [Gases - Toxic]:may be fatal if inhaled or absorbed through skin. Vapors may be irritating and/or corrosive. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause environmental contamination. (ERG, 2024)· TOXICmay be fatal if inhaled or absorbed through skin.· Vapors may be irritating and/or corrosive.· Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite.· Fire will produce irritating, corrosive and/or toxic gases.· Runoff from fire control or dilution water may cause environmental contamination. |
| Gefahrenübersicht | Concentrations inside fumigated structures are as high as 4000 to 40,000 ppm. Inhalation exposure may cause pulmonary edema. [ACGIH] Because sulfuryl fluoride is heavier than air, workers who re-enter a treated area are at risk for fatal hypoxia. Muscle twitching and seizures have been reported after acute poisoning. [EPA Pesticides, p. 161] Possible frostbite from contact with liquid[NIOSH] The exact toxic mechanism is not known, but increased fluoride ion concentrations have been found in poisoned victims. Systemic fluorosis may result from sulfuryl fluoride poisoning. Fluoride can cause hypocalcemia and hyperkalemia with secondary arrhythmias and central nervous effects including agitation, tetany, and seizures. [AHLS, p. 266-7] This gas has no warning properties, but chloropicrin is often added. After chronic inhalation studies, animals have evidence of liver injury. [HSDB] See FLUORIDES. |
| DOT-Nummer und Handbuch | 2191 123 |
| Reaktive Gruppe | Fluoride Salts, Soluble |
| UN-Einstufung | UN Hazard Class: 2.3 |
| Special Reports | USEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - Sulfuryl Fluoride p.5-9. EPA 738-F-93-012 (1992) This document reviews information available on sulfuryl flouride as on 1992 (before this substance was considered as a replacement for methyl bromide).[Available from, as of February 15, 2007: http://www.epa.gov/pesticides/reregistration/status.htm]Sulfuryl Fluoride, Pesticide ToleranceFederal RegisterJuly 15, 2005 http://www.epa.gov/EPA-PEST/2005/July/Day-15/p13982.htm contains most recent information on EPA's evaluation of this chemical. |
| FIFRA-Anforderungen | As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Sulfuryl fluoride is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0176Pesticide type: antimicrobialRegistration Standard Date: 06/30/85Case Status: RED Approved 09/93OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.Active ingredient (AI): Sulfuryl fluorideData Call-in (DCI) Date(s): 07/20/90, 11/10/92, 09/30/93AI Status: OPP has completed a Reregistration Eligibility Decision (RED) document for the case/AI. |
| Brandbekämpfung | Excerpt from ERG Guide 123 [Gases - Toxic]:SMALL FIRE: Dry chemical or CO2.LARGE FIRE: Water spray, fog or regular foam. Do not get water inside containers. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devicesicing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest. Half-upright position. Refer immediately for medical attention.ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer immediately for medical attention .ON FROSTBITE: rinse with plenty of water. Refer immediately for medical attention. Keep rinsing during transport for medical attention. |
| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep unauthorized personnel away.· Stay upwind, uphill and/or upstream.· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).· Ventilate closed spaces before entering, but only if properly trained and equipped.· Do not touch or walk through spilled material.· Stop leak if you can do it without risk.· If possible, turn leaking containers so that gas escapes rather than liquid.· Prevent entry into waterways, sewers, basements or confined areas.· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.· Do not direct water at spill or source of leak.· Isolate area until gas has dispersed. |
| Erste Hilfe | Excerpt from NIOSH Pocket Guide for Sulfuryl fluoride:Eye: FROSTBITE - If eye tissue is frozen, seek medical attention immediatelyif tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.Skin: FROSTBITE - If frostbite has occurred, seek medical attention immediatelydo NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2024)General First Aid:· Call 911 or emergency medical service.· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.· Move victim to fresh air if it can be done safely.· Administer oxygen if breathing is difficult.· If victim is not breathing:-- DO NOT perform mouth-to-mouth resuscitationthe victim may have ingested or inhaled the substance.-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.· Remove and isolate contaminated clothing and shoes.· For minor skin contact, avoid spreading material on unaffected skin.· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.· For severe burns, immediate medical attention is required.· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.· Keep victim calm and warm.· Keep victim under observation.· For further assistance, contact your local Poison Control Center.· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.Specific First Aid:· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.(General first aid procedures)Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.Breathing: Respiratory support |
| Sichere Lagerung | Fireproof if in building. Cool. Ventilation along the floor. |
| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA).· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016]. |
| Brandbekämpfungsverfahren | If material involved in fire: extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. |
| Lagerbedingungen | Store in dry, cool, well ventilated area under lock and key. Post as a pesticide storage area. If the storage area is in an occupied building, the storage area must have either 1) a forced air ventilation system that meets required local ordinances for the storage of hazardous materials and operates continuouslyor 2) be equipped with a permanently mounted and properly maintained and functioning sulfuryl fluoride monitoring device designed to alert occupants of the building if sulfuryl fluoride in the air of the storage area is greater than 1 ppm. Store cylinders upright, secured to a rack or wall to prevent tipping. Do not contaminate water, food, or feed by storage. Cylinders should not be subjected to rough handling or mechanical shock such as dropping, bumping, dragging, or sliding. Do not transport any cylinders in closed vehicles where they occupy the same common airspace as personnel. Transport securely only in an upright position. Do not remove valve protection bonnet and safety cap until immediately before use. Replace safety cap and valve protection bonnet when cylinder is not in use. /Vikane/MAY BE STORED IN COMPRESSED FORM IN STEEL CYLINDERS OR IN GASOMETER OVER SULFURIC ACID.Store cylinders upright, away from heat in a secured, well ventilated area away from dwellings and work areas. Do not contaminate or store near food, feed, or drugs. When not in use, all full and partially used or empty cylinders must have the valve closed and the valve cover hood securely in place. |
| Reinigungsverfahren | Leak Procedures: Evacuate immediate area of leak. Use a NIOSH ... approved positive pressure self-contained breathing apparatus (SCBA, not SCUBA) or combination air-supplied/SCSA respirator ... for entry into affected areas to correct problem. Move leaking or damaged cylinder outdoors or to an isolated location, observing strict safety precautions. Work upwind if possible. Do not permit entry into leakage area by unprotected persons until concentration of fumigant in the breathing zone is determined to be 1 part per miliion (ppm) or less, as determined by a detection device with sufficient sensitivity ... /Vikane/ |
| Freisetung ohne Brand | Excerpt from ERG Guide 123 [Gases - Toxic]:Do not touch or walk through spilled material. Stop leak if you can do it without risk. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Do not direct water at spill or source of leak. Isolate area until gas has dispersed. (ERG, 2024) |
| Entsorgungsverfahren | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.Cylinder and Product Disposal: Promptly return all empty cylinders to your distributor of Vikane. Follow proper cylinder handling directions above. Pesticide wastes are acutely hazardous, Improper disposal of excess pesticide is a violation of Federal law. If these wastes cannot be disposed of by use according to label instructions, consult your State Pesticide or Environmental Control Agency, or the Hazardous Waste Representative at the nearest EPA Regional Office for guidance. /Vikane/The following disposal method has been suggested ... allow gas to flow into a mixed solution of caustic soda and slaked lime. |
| Verschüttetes entsorgen | Evacuate danger area! Consult an expert! Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Isolate the area until the gas has dispersed. Shut off cylinder if possible. Remove vapour with fine water spray. Do NOT let this chemical enter the environment. |
| Wechselwirkungen | Therapeutic treatment with calcium gluconate was evaluated ... Rats were exposed to 4000 or 10,000 ppm sulfuryl fluoride for 45 or 16 min (sufficient to result in 100% lethality within 3 hr), respectively, or were treated ip with calcium gluconate prior to and after exposure to sulfuryl fluoride. Animals which were still alive 3 days after exposure ... were considered to have survived. In separate groups of rats, serum fluoride levels were determined in rats exposed to sulfuryl fluoride alone or pretreated with calcium gluconate. Four of five rats pretreated with calcium gluconate prior to exposure to 4000 ppm sulfuryl fluoride survived 3 days after dosing. The other rat died 90 min after exposure. Treatment with calcium gluconate after exposure to sulfuryl fluoride was not effective. While survival was incr in rats pretreated with calcium gluconate, the surviving animals were extremely debilitated with no apparent protection from convulsions. Animals pretreated with calcium gluconate did not survive exposure to 10,000 ppm sulfuryl fluoride. Admin of calcium gluconate resulted in approx 10% incr in serum calcium levels and did not appear to affect serum fluoride or magnesium levels.Since the cause of death in rats pre- or postexposure treated with calcium gluconate appeared to be due to convulsions, rats were pretreated with 1 of 3 anticonvulsants (phenobarbital, diazepam, or diphenylhydantoin) prior to exposure to 4000 ppm sulfuryl fluoride or were treated postexposure with phenobarbital and diazepam ... Phenobarbital was the most effective anticonvulsant followed by diazepam with 5 of 5 and 4 of 5 pretreated with phenobarbital and diazepam surviving exposure to 4000 ppm for 50 min. Diphenylhydantoin accentuated the adverse effects of sulfuryl fluoride. At higher concn of sulfuryl fluoride, 10,000 ppm, phenobarbital was also ineffective. |
| Zielorgane | Eyes, skin, respiratory system, central nervous system, kidneys |
| Unerwünschte Wirkungen | Neurotoxin - Other CNS neurotoxinOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. |
| Expositionspfade | The substance can be absorbed into the body by inhalation.inhalation, skin and/or eye contact (liquid) |
| Milk Concentrations | /Experimental/ The principal route of fluoride excretion is via the urine. Some excretion takes place through sweat and feces, and fluoride also appears in saliva. Fluoride crosses the placentait rarely seems to be excreted in milk to any significant extent. /Fluorides/ |
| Ökotoxizitätsauszüge | /PLANTS/ Orchid plants and a grapefruit tree suffered considerable damage when vikane (SO2F2) was used to fumigate a termite-ridden house 15-30 ft away. Orchids developed black rot and leaf tip rot after 1 wk, and the tree lost its leaves and fruit after 4 days./PLANTS/ ... Phytotoxic but with little effect on the germination of weed & crop seeds. |
| Signs and Symptoms | Sore throat. Cough. Shortness of breath. Nausea. Vomiting. Weakness. Heart palpitations. Convulsions. Unconsciousness.ON CONTACT WITH LIQUID: FROSTBITE.Redness. ON CONTACT WITH LIQUID: FROSTBITE.conjunctivitis, rhinitis, pharyngitis, paresthesialiquid: frostbite: In Animals: narcosis, tremor, convulsionspulmonary edemakidney injury |
| ICSC Environmental Data | The substance is very toxic to aquatic organisms. |
| Medical Surveillance | Consider the points of attack /respiratory system, central nervous system/ in preplacement and periodic physical examination. |
| Human Toxicity Excerpts | /SIGNS AND SYMPTOMS/ ... Vikane is a gas which has no warning properties such as odor or eye irritation. (However, chloropicrin is used as a warning agent and is a known lachrymator). Early symptoms of exposure to Vikane are respiratory irritation and central nervous system depression. Excitation may follow. Slowed movement, reduced awareness, and slow or garbled speech may be noted. Prolonged exposure can produce lung irritation, pulmonary edema, nausea, and abdominal pain. Repeated exposure to high concentrations can result in significant lung and kidney damage. Single exposures at high concentrations have resulted in death. ... /Vikane//SIGNS AND SYMPTOMS/ Poisonings and fatalities have been reported in humans following inhalation exposure to sulfuryl fluoride. The severity of these effects has depended on the concentration of sulfuryl fluoride and the duration of exposure. Short-term inhalation exposure to high concentrations has caused respiratory irritation, pulmonary edema, nausea, abdominal pain, central nervous system depression, and numbness in the extremities. ... Prolonged chronic inhalation exposures to concentrations of sulfuryl fluoride gas significantly above the threshold limit value (TLV) of 5 ppm have caused fluorosis in humans because sulfuryl fluoride is converted to fluoride anion in the body. Fluorosis is characterized by binding of fluoride anion to teeth (causing mottling of the teeth) and to bone. Sulfuryl fluoride and fluoride anion are the residues of concern associated with sulfuryl fluoride. /Fluoride anion/[EPA 40 CFR Part 180/SIGNS AND SYMPTOMS/ When released from pressurized steel cylinders, sulfuryl fluoride causes freezing of skin and eye tissues on contact.[EPA 40 CFR Part 180/SIGNS AND SYMPTOMS/ Accidental human exposure caused nausea, vomiting, cramps, itching.For more Human Toxicity Excerpts (Complete) data for SULFURYL FLUORIDE (16 total), please visit the HSDB record page. |
| Non-Human Toxicity Excerpts | /LABORATORY ANIMALS: Acute Exposure/ Male rats that inhaled 4000 ppm sulfuryl fluoride survived about 2.5 hourstonic convulsions were observed just prior to death. With exposure to concentrations up to 40,000 ppm, the time to death decreased in a concentration-dependent manner. Pulmonary edema, cyanosis, respiratory arrest, and convulsions preceded death at the higher concentrations. Because circulating fluoride was elevated in the animals that died, the authors considered that the toxicity of sulfuryl fluoride was due, at least in part, to fluoride./LABORATORY ANIMALS: Acute Exposure/ Mice are more sensitive than rats to the acute effects of inhaled sulfuryl fluoride, whereas rabbits were considered somewhat less sensitivetonic convulsions were recorded after exposure and aveolar hemorrhage/pulmonary congestion was seen in those that inhaled greater than or equal to 6000 ppm./LABORATORY ANIMALS: Acute Exposure/ Liq sulfuryl fluoride directly contacting skin can result in frostbite ... Animals exposed to lethal doses of sulfuryl fluoride had tremors and convulsions. The convulsions were characterized by stiffening of the animal to a very rigid position and the toppling over backward. Excessive salivation, loss of bladder control, and chromodacryorrhea were observed also./LABORATORY ANIMALS: Acute Exposure/ B6C3F1 mice were exposed to 400, 600, or 1000 ppm for 4 hr ... All animals died within 90 min after termination of the exposure to 1000 ppm and within 6 days following exposure to 600 ppm. Body tremors were observed in several female mice shortly after exposure to 600 ppm and animals surviving after the exposure period were lethargic prior to death. There were no clinically visible effects noted in mice exposed to 400 ppm ...[Krieger, R. (ed.). Handbook of Pesticide Toxicology. Volume 2, 2nd ed. 2001. Academic Press, San Diego, California., p. 1882]For more Non-Human Toxicity Excerpts (Complete) data for SULFURYL FLUORIDE (52 total), please visit the HSDB record page. |
| Evidence for Carcinogenicity | Cancer Classification: Not Likely to be Carcinogenic to Humans |
| Berufliche Expositionsstufe (OEB) | A |
| Arbeitsplatzgrenzwert (OEL) | TWA: 5 ppm (20 mg/m3), STEL: 10 ppm (40 mg/m3) |
| Sofort lebensgefährliche Konzentration | 200 ppm |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 2191 |
| R-Sätze (R) | 23/25-36/37/38-50-48/20-23 |
| Toxizität | guinea pig,LD50,oral,100mg/kg (100mg/kg),Dow Chemical Company Reports. |
| Gefahrensymbole | C,N,T |
| hazard_note | Corrosive |
| Sicherheitshinweise (S) | 23-37/39-45-61-60-63 |
| Gefahrenklasse | 2.3 |
| Gefahrstoffdaten | 2699-79-8(Hazardous Substances Data) |
Anwendungen & Verwendung
Verwenden
Sulfuryl fluoride is another promising chemical, which is widely used for control of termites, and stored-product insects. This chemical shows considerable promise and is undergoing registration procedures as replacement for methyl bromide in several countries including the United States, Great Britain, Italy, and France. The fumigant has vapour pressure of about ten times higher (13,442 mm of Hg at 25oC) than that of methyl bromide and hence it is more penetrative into treated commodities which is a significant benefit in situations where insect infestations are located deep within cracks or machinery in premises such as flour mills . The fumigant has several other advantages as a replacement for methyl bromide; it is nonreactive with structural materials and components of electronic equipment, is non flammable and has not caused problems of taint following treatment of a wide range of materials. However the sulfuryl fluoride was found to be less effective in controlling the insect eggs.