Cevipabulin Succinate
Grundinformationen
- CAS
852954-81-5- Standard-SMILES
CNCCCOc1cc(F)c(-c2c(Cl)nc3ncnn3c2N[C@@H](C)C(F)(F)F)c(F)c1.O.O.O=C(O)CCC(=O)O- InChIKey
FWNIBMRSBSSPNP-DXYFNVQQSA-N- Summenformel
- C22H28ClF5N6O7
- Durchschnittliche Molmasse
- 618,9 g/mol
Überblick
Cevipabulin Succinate is the succinate salt form of cevipabulin, a synthetic, water soluble tubulin-binding agent with potential antineoplastic activity. Cevipabulin binds at the vinca-binding site on tubulin, but seems to act more similar to taxane-site binding agents in that it enhances tubulin polymerization and does not induce tubulin depolymerization. This stabilizes tubulin and prevents microtubule disassembly. The disruption in microtubule dynamics may eventually inhibit cell division and reduce cellular growth.
Namen und Bezeichner
- Bevorzugter Name
- Cevipabulin Succinate
- IUPAC
- butanedioic acid;5-chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine;dihydrate
Namen und Synonyme
Cevipabulin succinateCevipabulin succinate [USAN]852954-81-5UNII-8XI0CX98LY8XI0CX98LYTTI-237 SUCCINATE DIHYDRATECevipabulin succinate (USAN)CEVIPABULIN SUCCINATE [WHO-DD]5-CHLORO-6-(2,6-DIFLUORO-4-(3-(METHYLAMINO)PROPOXY)PHENYL)-N-((1S)-2,2,2-TRIFLUORO-1-METHYLETHYL)(1,2,4)TRIAZOLO(1,5-A)PYRIMIDIN-7-AMINE SUCCINATE DIHYDRATERefChem:124738cevipabulin succinate dihydrateSCHEMBL4211390
Weitere Namen anzeigen
CHEMBL2107323butanedioic acid;5-chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine;dihydrateD08889Q272711595-Chloro-6-(2,6-difluoro-4-(3-(methylamino)propoxy)phenyl)-N-((1S)-2,2,2-trifluoro-1- methylethyl)-(1,2,4)triazolo(1,5-a)pyrimidin-7-amine butanedioate dihydrate5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-n-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine succinate salt dihydrate
Datenbank-Bezeichner
- CAS
852954-81-5- PubChem CID
- 17755247
- ChEMBL
CHEMBL2107323
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 153 Ų
- H-Brücken-Donoren
- 6
- H-Brücken-Akzeptoren
- 17
- Frei drehbare Bindungen
- 11
- Schwere Atome
- 41
- Formalladung
- 0
- Komplexität
- 659
Anbieter
Wird geladen…
Öffentliche Anfragen
Wird geladen…
Zugehörige Reaktionen
1
Notizen zur Verbindung
Wird geladen…