HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Hydroxypyrimidine-5-carboxamide
2-hydroxypyriMidine-5-carboxaMide · 5-Pyrimidinecarboxamide, 1,2-dihydro-2-oxo- · 2-oxo-1,2-dihydro-pyrimidine-5-carboxalic acid amide
Identifikatoren & physikalische Daten
| CAS No. | 1233198-67-8 |
|---|---|
| Summenformel | C5H5N3O2 |
| Durchschnittliche Molmasse | 139,11 g/mol |
| Monoisotopische Masse | 139,03817641 g/mol |
| SMILES | NC(=O)c1cnc(=O)[nH]c1 |
| InChIKey | GYUKNGCOAIIQNX-UHFFFAOYSA-N |
| PubChem CID | 46237367 |
Chemische & physikalische Eigenschaften
| XLogP | -1,6 |
|---|---|
| Polarare Oberfläche (TPSA) | 84,6 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 10 |
| Formalladung | 0 |
| Komplexität | 241 |
| Schmelzpunkt | 297-300 °C |
| Dichte | 1.63±0.1 g/cm3(Predicted) |
| pKa (Säurekonstante) | 8.26±0.10(Predicted) |
Sicherheit & Vorschriften
| Alarmwort | Warnung |
|---|---|
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302 |
Anwendungen & Verwendung
Verwenden
2-Oxo-1,2-dihydropyrimidine-5-carboxamide is a building block related to Favipiravir(F103350). Favipiravir is used for the treatment of advanced Ebola virus infection in a small animal model. Favipiravir suppressed the replication of Zaire Ebola virus and prevented a lethal outcome in 100% of the animals. Based on the studies, Favipiravir can be a candidate for the treatment of Ebola hemorrhagic fever.