N,N''-Diphthaloyl-L-cystine
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Grundinformationen
- CAS
29588-96-3- Standard-SMILES
O=C(O)[C@H](CSSC[C@@H](C(=O)O)N1C(=O)c2ccccc2C1=O)N1C(=O)c2ccccc2C1=O- InChIKey
GUQBSPYSVBNDBP-HOTGVXAUSA-N- Summenformel
- C22H16N2O8S2
- Durchschnittliche Molmasse
- 500,5 g/mol
Namen und Bezeichner
- Bevorzugter Name
- N,N''-Diphthaloyl-L-cystine
- Englischer Name
- N,N''-Diphthaloyl-L-cystine
- Summenformel
- C22H16N2O8S2
- Molmasse
- 500.5
Namen und Synonyme
-Diphthaloyl-L-cystineN,N'-Diphthaloyl-L-cystineN,N''-Diphthaloyl-L-cystine2H-Isoindole-2-acetic acid, α,α'-[dithiobis(methylene)]bis[1,3-dihydro-1,3-dioxo-, [R-(R*,R*)]- (9CI)
Datenbank-Bezeichner
- CAS
29588-96-3
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 750.1 · 750.1±60.0 °C(Predicted)
- Dichte
- 1.679 · 1.679±0.06 g/cm3(Predicted)
- pka
- 2.78 · 2.78±0.10(Predicted)
Chemie und Industrie
Anwendungen
VerwendenN,N''-Diphthaloyl-L-cystine is used in the synthesis of Di-O-cysteinyl-glycinoyl Curcumin (D455600). Di-O-cysteinyl-glycinoyl curcumin is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcu
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