1-[[4-(4-Nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
Grundinformationen
- CAS
85008-71-5- Standard-SMILES
O=C1CN(N=Cc2cc(-c3ccc([N+](=O)[O-])cc3)co2)C(=O)N1- InChIKey
VIDNGZZBZXHXHP-UHFFFAOYSA-N- Summenformel
- C14H10N4O5
- Durchschnittliche Molmasse
- 314,25 g/mol
- Monoisotopische Masse
- 314,06511943
Namen und Bezeichner
- Bevorzugter Name
- 1-[[4-(4-Nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
- IUPAC
- 1-[[4-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
- Englischer Name
- DANTROLENE
- Summenformel
- C14H10N4O5
- Molmasse
- 314.25
Namen und Synonyme
DANTROLENEDANTROLENE USP/EP/BPDantrolene free baseDANTROLENE FREE BASE (FOR R&D ONLY)2,4-Imidazolidinedione,1-[[[4-(4-nitrophenyl)-2-furanyl]meth...
Datenbank-Bezeichner
- CAS
85008-71-5- PubChem CID
- 131637031
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 1,7
- Polarare Oberfläche (TPSA)
- 121 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 23
- Formalladung
- 0
- Komplexität
- 524
Physikochemische Eigenschaften
- Schmelzpunkt
- 236 °C · >236°C (dec.)
- Dichte
- 1.57 · 1.57±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- Löslichkeit
- DMSO (Slightly), Methanol (Very Slightly, Sonicated)
- Aggregatzustand
- Solid
- pka
- 7.5 · pKa 7.5 (Uncertain)
- Farbe
- Yellow to Dark Yellow
- Stabilität
- Hygroscopic
Chemie und Industrie
Anwendungen
BeschreibungDantrolene is a drug that causes spastic muscle contraction. Unlike other muscle relaxants, it has a direct effect on the contractile mechanism by interfering in the process of calcium ion release from the sarcoplasmic reticulum. This results in a lack of coordination in the mechanism of excitation––contraction of skeletal muscle, which has a greater effect on fast muscle fibers than on slow muscle fibers.
VerwendenDantrolene is used for controlling the onset of clinical spasticity resulting from serious clinical cases such as wounds, paralysis, cerebral palsy, and disseminated sclerosis. Synonyms of this drug are dantrium and danlen.
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深圳市思美泉生物科技有限公司17683743113;18038040196 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
Auschemicals Pty Ltd+86-13822340013 · [email protected]
成都圣美凯生物科技有限公司028-85157043 15882256948 · [email protected]
Hefei TNJ Chemical Industry Co.,Ltd.+86-0551-65418684 +86-18949823763 · [email protected]
Dideu Industries Group Limited+86-29-81148696 +86-15129568250 · [email protected]
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