Calpain Inhibitor XII
Grundinformationen
- CAS
181769-57-3- Standard-SMILES
CCCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCc1ccccn1- InChIKey
PLVWMBFPIAQRHK-UHFFFAOYSA-N- Summenformel
- C26H34N4O5
- Durchschnittliche Molmasse
- 482,6 g/mol
- Monoisotopische Masse
- 482,2529202
Namen und Bezeichner
- Bevorzugter Name
- Calpain Inhibitor XII
- IUPAC
- benzyl N-[1-[[1,2-dioxo-1-(pyridin-2-ylmethylamino)hexan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
- Englischer Name
- CALPAIN INHIBITOR XII
- Summenformel
- C26H34N4O5
- Molmasse
- 482.57
Namen und Synonyme
Calpain Inhibitor XII181769-57-3(Rac)-Calpain Inhibitor XIICHEMBL132586Benzyl (1-((1,2-dioxo-1-((pyridin-2-ylmethyl)amino)hexan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamatebenzyl N-[1-[[1,2-dioxo-1-(pyridin-2-ylmethylamino)hexan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateZ-L-Nva-CONH-CH2-2-Pyorb1704918C26H34N4O5GLXC-23176EX-A6690BDBM50053822
Weitere Namen anzeigen
PLVWMBFPIAQRHK-UHFFFAOYSA-NCarbamic acid, [3-methyl-1-[[[1-[oxo[(2-pyridinylmethyl)amino]acetyl]butyl]amino]carbonyl]butyl]-, phenylmethyl ester (9CI)
MFCD06411395AKOS040744953BC177426DA-59638MS-28977HY-116171CS-0064270G14233
Datenbank-Bezeichner
- CAS
181769-57-3- PubChem CID
- 16760340
- ChEMBL
CHEMBL132586
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,5
- Polarare Oberfläche (TPSA)
- 126 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 14
- Schwere Atome
- 35
- Formalladung
- 0
- Komplexität
- 693
Physikochemische Eigenschaften
- Dichte
- 1.167 · 1.167±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 16 mg/ml · ≤16mg/ml in ethanol;16mg/ml in DMSO;20mg/ml in dimethyl formamide
- Aggregatzustand
- crystalline solid
- pka
- 10.58 · 10.58±0.46(Predicted)
- Farbe
- White to yellow
Chemie und Industrie
Anwendungen
BeschreibungCalpain inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki = 19 nM), with lower affinities for calpain II (m-calpain, Ki = 120 nM) and cathepsin B (Ki = 750 nM). Calpain inhibitors, including this compound, have been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.
VerwendenA cell-permeable dipeptidyl -ketoamide compound that acts as a potent, selective, reversible, and active site inhibitor of calpain-1
Anbieter24 Anbieter
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
Aladdin Scientific[email protected]
Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
VDM Biochemicals0330-2528181 · [email protected]
上海尺水药物研究有限公司[email protected] 13564957716 · [email protected]
NANJING YINGWEN BIOTECHNOLOGY CO LTD+8613382787392 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海一研生物科技有限公司021-69985186 13611928337 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
武汉多普乐生物医药有限公司+86-02787215551 19945035818 · [email protected]
BOC Sciences16314854226 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
武汉沃格达生物科技有限公司15071299552 · [email protected]
南通全益生物科技有限公司+86-0513; 18051384581 · [email protected]
杭州肽佳生物科技有限公司0571-87213919 15967184799 · [email protected]
上海凯裕医药科技有限公司17317130613 · [email protected]
Wuhan Topule Biopharmaceutical Co., Ltd+86-18327326525 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
ChemeGen 中国18818260767 · [email protected]
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…