(3S)-3-Methyl-methylester Heptanoic Acid

synthetische(3S)-3-Methyl-methyl heptanoate was prepared by reacting (S)-2-(2-hexyl)malonic acid dimethyl ester with LiCl. The specific synthesis procedure is as follows: Take a 500 mL four-neck flask and add LiCl (6.21 g, 146.5 mmol), (S)-2-(2-hexyl)malonic acid dimethyl ester (15.84 g, 73.2 mmol) and DMSO (240 mL) in sequence, followed by H₂O (5 mL). Gradually heat to 180 °C and reflux for 4 hours. Once the reaction was confirmed to be complete by TLC, the reaction was terminated. The mixture was cooled to room temperature, and the reaction mixture was poured into a sodium chloride solution (500 mL, 12% aqueous solution); ethyl acetate (500 mL) was then added. allowed to stand until separation, the organic phase was separated off, the aqueous phase was washed with ethyl acetate (3 × 200 mL), the organic phases were combined, washed with H₂O (3 × 200 mL), dried over anhydrous sodium sulphate, and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 10:1) to afford a colourless oily liquid, (3S)-3-Methyl-methyl ester of heptanoic acid (8.64 g, 74% yield).