Carbidopa monohydrate
Grundinformationen
- CAS
1276197-58-0- Standard-SMILES
C[C@@](Cc1ccc(O)c(O)c1)(NN)C(=O)O.O- InChIKey
QTAOMKOIBXZKND-PPHPATTJSA-N- Summenformel
- C10H16N2O5
- Durchschnittliche Molmasse
- 244,24 g/mol
Überblick
Carbidopa is the hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an antiparkinson drug, a dopaminergic agent, an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor and an antidyskinesia agent. It is a member of hydrazines, a monocarboxylic acid, a member of catechols and a hydrate. It contains a carbidopa (anhydrous).
Namen und Bezeichner
- Bevorzugter Name
- Carbidopa monohydrate
- IUPAC
- (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid;hydrate
- Englischer Name
- (S)-(-)-CARBIDOPA-D3 H2O (RING-D3)
- Summenformel
- C10H16N2O5
- Molmasse
- 244.25
Namen und Synonyme
Carbidopa Monohydrate38821-49-7Carbidopa hydrateDTXSID50904589RefChem:1081191DTXCID101333716(2S)-2-(3,4-Dihydroxybenzyl)-2-hydrazinopropanoic acid monohydrateMFCD00889211S-(-)-Carbidopa monohydrate(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid;hydrate(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrateCarbidopa-1-wasser
Weitere Namen anzeigen
Carbidopa-d3monohydrate(S)-(-)-CARBIDOPA-D3 H2O (RING-D3)(S)-(-)-Carbidopa D3 H2OQ: What is (S)-(-)-Carbidopa D3 H2O Q: What is the CAS Number of (S)-(-)-Carbidopa D3 H2O Q: What is the storage condition of (S)-(-)-Carbidopa D3 H2O Q: What are the applications of (S)-(-)-Carbidopa D3 H2O
Carbidopa (monohydrate)(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1)(S)-(-)-Carbidopa MonohydrateUNII-MNX7R8C5VOCarbidopa RSCarbidopa CRSCarbidopa; (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid monohydrateCarbidopa (USP)
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 117 Ų
- H-Brücken-Donoren
- 6
- H-Brücken-Akzeptoren
- 7
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 17
- Formalladung
- 0
- Komplexität
- 261
Physikochemische Eigenschaften
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- DMSO: slightly soluble,Methanol: slightly soluble
- Aggregatzustand
- A solid
- Farbe
- White to off-white
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (60.2%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 108 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (60.2%)
Sicherheitsdaten
- Alarmwort
- Warnung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302
Chemie und Industrie
Anwendungen
VerwendenLabelled analogue of (S)-(-)-Carbidopa, a peripheral decarboxylase inhibitor, commonly used in combination with L-DOPA (D533751) for the treatment of Parkinsonism. S(-)-Carbidopa has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.
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