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2,4-Diaminophenoxyethanol Dihydrochloride

HCID 178747020
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Grundinformationen

CAS
126596-25-6
Standard-SMILES
Cl.Nc1ccc(OCCO)c(N)c1
InChIKey
PBVFDMZFBPZIMC-UHFFFAOYSA-N
Summenformel
C8H13ClN2O2
Durchschnittliche Molmasse
204,65 g/mol

Namen und Bezeichner

Bevorzugter Name
2,4-Diaminophenoxyethanol Dihydrochloride
IUPAC
2-(2,4-diaminophenoxy)ethanol;hydrochloride
Englischer Name
Ethanol, 2-(2,4-diaMinophenoxy)-, hydrochloride
Summenformel
C8H13ClN2O2
Molmasse
204.65402

Namen und Synonyme

2,4-Diaminophenoxyethanol dihydrochlorideRefChem:105969266422-95-5Ethanol, 2-(2,4-diaminophenoxy)-, dihydrochloride847455-21-4SCHEMBL33976SCHEMBL29356501DTXSID00624725AKOS0158903992-(2,4-diaminophenoxy)ethan-1-ol hydrochloride2-(2,4-Diaminophenoxy)ethan-1-ol--hydrogen chloride (1/1)Ethanol, 2-(2,4-diaMinophenoxy)-, hydrochloride
Weitere Namen anzeigen
2-(2,4-diaminophenoxy)-Ethanol hydrochloride (1:1)Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:1)

Datenbank-Bezeichner

CAS
126596-25-6
EC Number
266-357-1

Eigenschaften

Berechnete StruktureigenschaftenWird ergänzt

Polarare Oberfläche (TPSA)
81,5 Ų
H-Brücken-Donoren
4
H-Brücken-Akzeptoren
4
Frei drehbare Bindungen
3
Schwere Atome
13
Formalladung
0
Komplexität
132

Experimentelle und physikochemische Eigenschaften

Chemical ClassesNitrogen Compounds -> Other Aromatics (Nitrogen)
Cosmetics · 2 Einträge

Cosmetic ingredients (2,4-Diaminophenoxyethanol Dihydrochloride) -> CIR (Cosmetic Ingredient Review)

Hair dyeing

Physical DescriptionSolid; [MSDSonline] Light grey to light pink solid; [EC]

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 6 Einträge

Warning

H302 (99.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P333+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 153 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

Gefahrenhinweise

Regulatory Information · 3 Einträge

Chemical: Ethanol, 2-(2,4-diaminophenoxy)-, dihydrochloride

Status: Active Update: 14-07-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/10194

Ethanol, 2-(2,4-diaminophenoxy)-, dihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - Ethanol, 2-(2,4-diaminophenoxy)-, dihydrochloride: Human health tier II assessment
Hazards Summary · 1 Eintrag

No evidence of mutagenicity; [HSDB] LD50 (gavage) in rats is approximately 1000 mg/kg; Irritating to eyes but not skin in rabbits; Not sensitizing to guinea pig skin; A moderate skin sensitizer based on local lymph node assay; Brown discoloration of the thyroid and spleen hemosiderosis observed in 13-week gavage study with rats at highest tested dose (100 mg/kg); Some evidence of mutagenicity; Teratogenic effects observed in rats (NOAEL for both maternal and embryo-fetal toxicity is 20 mg/kg/day); [EC] Harmful if swallowed; May cause skin sensitization; [Aldrich MSDS]

Special Reports

Chemie und Industrie

Pharmakologische Informationen

Absorption, Distribution and Excretion · 1 Eintrag

THE CUTANEOUS PENETRATION OF THE OXIDATION DYESTUFF 2,4-DIAMINOPHENOXYETHANOL EITHER ALONE OR WHEN FORMULATED WITH OTHER DYESTUFFS, & UNDER EXPERIMENTAL CONDITIONS, HAS BEEN EVALUATED IN THE HAIRLESS RAT USING (14)C-LABELED MOLECULES. NO FIXATION OF THE DYESTUFFS INVESTIGATED WHICH DO PASS THROUGH THE CUTANEOUS BARRIER IS FOUND IN EITHER LIVER OR THYROID OF THE EXPERIMENTAL ANIMALS, 4 DAYS AFTER THEIR TOPICAL APPLICATION.

Verwendung und Herstellung

Uses · 4 Einträge

CIR ingredient: 2,4-Diaminophenoxyethanol Dihydrochloride

Used in hair dyes; [HSDB]

Dressing Hair [Category: Other]

USED AS A COMPONENT OF HAIR-DYES

Household ProductsInformation on 58 consumer products that contain 2-(2,4-Diaminophenoxy)ethanol dihydrochloride in the following categories is provided:
Use ClassificationCosmetics -> Hair dyeing
General Manufacturing InformationEthanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2): ACTIVE

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· 1 Eintrag

EVIDENCE IS GIVEN SUPPORTING TESTING OF THE CLASS OF COMPOUNDS PHENYLENEDIAMINES FOR THEIR TOXIC EFFECTS ON HUMAN HEALTH AND THE ENVIRONMENT. THE RESULTS OF TOXICITY TESTING OF 22 COMPOUNDS ARE TABULATED AS ARE THE EFFECTS FOR WHICH TESTING IS BEING CONSIDERED FOR 13 COMPOUNDS, AND THE USES OR POTENTIAL USES OF 47 PHENYLENEDIAMINES.[UNITED STATES EPA; PHENYLENEDIAMINES; RESPONSE TO INTERAGENCY TESTING COMMITTEE; FED REGIST 47(5) 973 (1982)]

Hazard Classes and Categories · 2 Einträge

Acute Tox. 4 (99.3%)

Acute toxicity - category 4

Toxikologische Informationen

Adverse EffectsSkin Sensitizer - An agent that can induce an allergic reaction in the skin.
Toxicity SummarySafe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org
Non-Human Toxicity Excerpts · 5 Einträge

2-(2',4'-DIAMINOPHENOXY)ETHANOL (DAPE) WAS EVALUATED FOR MUTAGENIC ACTIVITY IN THE SEX-LINKED RECESSIVE LETHAL TEST IN DROSOPHILA. RESULTS OBTAINED FROM BROOD-FRACTIONATING EXPERIMENTS INDICATED THAT FEEDING OF ADULT MALES WITH DAPE DID NOT LEAD TO AN INCREASE IN THE MUTATION FREQUENCY.

RESULTS OF TESTING FOR MUTAGENIC POTENTIAL IN A SHORT-TERM TEST WITH CHINESE HAMSTER OVARY CELLS IN VITRO SHOWED THAT DAPE IS NOT MUTAGENIC.

THERE WAS NO EVIDENCE OF GENOTOXIC POTENTIAL OF 2-(2',4'-DIAMINOPHENOXY)ETHANOL IN ESCHERICHIA COLI.

MUTAGENICITY ASSAYS INVOLVING SALMONELLA TYPHIMURIUM TA1538 & TA98, SCHIZOSACCHAROMYCES POMBE STRAIN SPADE6-60/RAD10-198H-, SACCHAROMYCES CEREVISIAE STRAIN D4, V79 CHINESE HAMSTER CELLS, & HELA HUMAN CELLS GROWN IN VITRO YIELDED NEGATIVE RESULTS. THE TESTED CONCN OF DAPE IN THE MUTATIONAL SYSTEM WAS HIGHER THAN THOSE TESTED FOR THE THREE POSITIVE CONTROLS. DAPE WAS TESTED UP TO THE SUBTOXIC LEVEL, AS 1 MM PRODUCED 100% LOSS OF VIABILITY IN THE CELLS.

For more Non-Human Toxicity Excerpts (Complete) data for 2-(2,4-DIAMINOPHENOXY)ETHANOL DIHYDROCHLORIDE (6 total), please visit the HSDB record page.