| Toxizitätsübersicht | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgIDENTIFICATION AND USE: Resorcinol is a white crystalline compound with a faint odor and bitter-sweet taste. It exists in at least two crystalline modifications. Crystalline resorcinol turns pale red in the presence of light and air and is hygroscopic. It is miscible in water. It is used in tanning, photographymanufacture of resins, resin adhesives, hexylresorcinol, p-aminosalicylic acid, explosives, dyes, tires, rubber productsin cosmeticsdyeing and printing textilesand as a reagent for zinc. It is not registered for current pesticide use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. Resorcinol is also a medication, used as an antifungal, antibacterial, mildly keratolytic and local irritant agent. It is a pharmaceutical agent used topically in dermatological treatments such as acne and related skin conditions. It could also be used in combination with the other acne treatment agents such as sulphur. HUMAN EXPOSURE AND TOXICITY: An application of 3-25% solution of resorcinol to skin may cause redness, itching, dermatitis, edema or corrosion of affected area. Potential symptoms of overexposure are irritation of eyes, skin, nose, throat, upper respiratory systemmethemoglobinemia, cyanosis, convulsionsrestlessness, bluish skin, increased heart rate, dyspneadizziness, drowsiness, hypothermia, hemoglobinuriaspleen, kidney, liver changes. ANIMAL STUDIES: Tests of 10% soln on rabbit eyes have caused pain, conjunctival inflammation, and vascularization of cornea. Dry, powdered resorcinol applied to rabbit eyes induced necrosis sufficient to cause perforation of cornea in some and extensive vascularization in others. A subcutaneous injection of 154 mg/kg in rats produced a thyroid disturbance (myxedema and goiter)an effect that did not occur when 50 mg/kg was injected. Resorcinol intake at 1000 mg/L via contaminated drinking water caused no detectable adverse effects on any reproduction or thyroid gland end points in rats. Groups of 10 male and female rats were given 0, 32, 65, 130, 260, or 520 mg/kg resorcinol by gavage 5 days/week for 13 weeks. Most animals given 520 mg/kg died. Daily doses of 65 mg/kg produced increased liver weights, but no other toxic effects were reported. Resorcinol showed no carcinogenic effect when tested by repeated skin application in mice and in 2-year gavage studies in rats and mice. Resorcinol was not mutagenic to Salmonella typhimurium strains TA1535, TA1537, TA98 or TA100 in presence or absence of rat liver postmitochondrial supernatant fraction. |
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