Ibuproxam
Grundinformationen
- CAS
73826-33-2- Standard-SMILES
CC(C)Cc1ccc(C(C)C(=O)NO)cc1- InChIKey
BYPIURIATSUHDW-UHFFFAOYSA-N- Summenformel
- C13H19NO2
- Durchschnittliche Molmasse
- 221,29 g/mol
Überblick
Ibuproxam is a hydroxamic acid obtained by formal condensation of the carboxy group of ibuprofen with the amino group of hydroxylamine. Used for treatment of pain and inflammation associated with musculoskeletal and joint disorders. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic and an iron chelator. It is functionally related to an ibuprofen.
Namen und Bezeichner
- Bevorzugter Name
- Ibuproxam
- IUPAC
- N-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide
- Englischer Name
- IBUPROXAM
- Summenformel
- C13H19NO2
- Molmasse
- 221.29546
Namen und Synonyme
Ibuproxam53648-05-8IbudrosIbuproxamumN-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamidep-Isobutylhydratropohydroxamic acidNSC-305528O3LD16O96ZCHEBI:76160DTXSID30866353Benzeneacetamide, N-hydroxy-alpha-methyl-4-(2-methylpropyl)-N-hydroxy-2-(4-(2-methylpropyl)phenyl)propanamide
Weitere Namen anzeigen
DeflogonEinecs 258-683-82-(4-Isobutylphenyl)propionohydroxamsaeure
NialenRefChem:147580DTXCID40814643M01AE132-(4-isobutylphenyl)propiohydroxamic acid258-683-8rac IbuproxamIbuproxam [INN]
Datenbank-Bezeichner
- CAS
73826-33-2- ChEMBL
CHEMBL292707- ChEBI
CHEBI:76160- UNII
- O3LD16O96Z
- EC Number
- 258-683-8
- Nikkaji
- J10.884G
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,8
- Polarare Oberfläche (TPSA)
- 49,3 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 16
- Formalladung
- 0
- Komplexität
- 220
Experimentelle und physikochemische Eigenschaften
LogP1.77
Melting Point119-121
Chemie und Industrie
Pharmakologische Informationen
ATC Code
M - Musculo-skeletal system
QM - Musculo-skeletal system
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
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