Proglumide
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Grundinformationen
- CAS
24485-90-3- Standard-SMILES
CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1- InChIKey
DGMKFQYCZXERLX-UHFFFAOYSA-N- Summenformel
- C18H26N2O4
- Durchschnittliche Molmasse
- 334,4 g/mol
Überblick
Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as an opioid analgesic, a cholinergic antagonist, a drug metabolite, an anti-ulcer drug, a gastrointestinal drug, a delta-opioid receptor agonist, a cholecystokinin antagonist and a xenobiotic metabolite. It contains a (R)-proglumide and a (S)-proglumide.
Namen und Bezeichner
- Bevorzugter Name
- Proglumide
- IUPAC
- 4-benzamido-5-(dipropylamino)-5-oxopentanoic acid
- Englischer Name
- 4-(Benzoylamino)-5-(dipropylamino)-5-oxovaleric acid
- Molmasse
- 0
Namen und Synonyme
proglumide6620-60-64-benzamido-5-(dipropylamino)-5-oxopentanoic acidBinosideXylamidedl-proglumideMilidNulsaGastrotopicMidelidUlcutinProglumida
Weitere Namen anzeigen
4-(Benzoylamino)-5-(dipropylamino)-5-oxovaleric acid4-(Phenylcarbonylamino)-5-(N,N-dipropylamino)-5-oxopentanoic acid
XydeProglumidumPromidW-5219DTXSID7023516242 DLCR-242(+-)-4-Benzamido-N,N-dipropylglutaramic acid
Datenbank-Bezeichner
- CAS
24485-90-3- ChEMBL
CHEMBL316561- ChEBI
CHEBI:32058- UNII
- EPL8W5565D
- EC Number
- 229-567-4
- Nikkaji
- J3.421E
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 2,4
- Polarare Oberfläche (TPSA)
- 86,7 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 10
- Schwere Atome
- 24
- Formalladung
- 0
- Komplexität
- 413
Experimentelle und physikochemische Eigenschaften
Human DrugsPharmaceuticals
Collision Cross Section
181.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
186.48 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (3 of 3) of all reports.
Not Classified
Aggregated GHS information provided per 3 reports by companies from 1 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory InformationStatus: Active Update: 29-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23299
Other Safety InformationIMAP assessments - Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (.+-.)-: Human health tier I assessment
Hazard Classes and CategoriesNot Classified
Chemie und Industrie
Pharmakologische Informationen
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
MeSH Pharmacological Classification
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
Verwendung und Herstellung
Use ClassificationPharmaceuticals
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