Proglumide

HCID 178783660CAS 24485-90-3
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Grundinformationen

Standard-SMILES
CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1
InChIKey
DGMKFQYCZXERLX-UHFFFAOYSA-N
Summenformel
C18H26N2O4
Durchschnittliche Molmasse
334,4 g/mol

Überblick

Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as an opioid analgesic, a cholinergic antagonist, a drug metabolite, an anti-ulcer drug, a gastrointestinal drug, a delta-opioid receptor agonist, a cholecystokinin antagonist and a xenobiotic metabolite. It contains a (R)-proglumide and a (S)-proglumide.

Namen und Bezeichner

Bevorzugter Name
Proglumide
IUPAC
4-benzamido-5-(dipropylamino)-5-oxopentanoic acid
Englischer Name
4-(Benzoylamino)-5-(dipropylamino)-5-oxovaleric acid
Molmasse
0

Namen und Synonyme

proglumide6620-60-64-benzamido-5-(dipropylamino)-5-oxopentanoic acidBinosideXylamidedl-proglumideMilidNulsaGastrotopicMidelidUlcutinProglumida
Weitere Namen anzeigen
4-(Benzoylamino)-5-(dipropylamino)-5-oxovaleric acid4-(Phenylcarbonylamino)-5-(N,N-dipropylamino)-5-oxopentanoic acid
XydeProglumidumPromidW-5219DTXSID7023516242 DLCR-242(+-)-4-Benzamido-N,N-dipropylglutaramic acid

Datenbank-Bezeichner

CAS
24485-90-3
ChEMBL
CHEMBL316561
ChEBI
CHEBI:32058
UNII
EPL8W5565D
EC Number
229-567-4
Nikkaji
J3.421E

Eigenschaften

Berechnete Struktureigenschaften

XLogP
2,4
Polarare Oberfläche (TPSA)
86,7 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
4
Frei drehbare Bindungen
10
Schwere Atome
24

Experimentelle und physikochemische Eigenschaften

Human DrugsPharmaceuticals
Collision Cross Section · 2 Einträge

181.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

186.48 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 3 Einträge

This chemical does not meet GHS hazard criteria for 100% (3 of 3) of all reports.

Not Classified

Aggregated GHS information provided per 3 reports by companies from 1 notifications to the ECHA C&L Inventory.

Gefahrenhinweise

Regulatory InformationStatus: Active Update: 29-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23299
Other Safety InformationIMAP assessments - Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (.+-.)-: Human health tier I assessment
Hazard Classes and CategoriesNot Classified

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 2 Einträge

A - Alimentary tract and metabolism

QA - Alimentary tract and metabolism

MeSH Pharmacological Classification · 1 Eintrag

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.

Verwendung und Herstellung

Use ClassificationPharmaceuticals

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