Paliperidone Palmitate
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Grundinformationen
- CAS
1794685-21-4- Standard-SMILES
CCCCCCCCCCCCCCCC(=O)OC1CCCn2c1nc(C)c(CCN1CCC(c3noc4cc(F)ccc34)CC1)c2=O- InChIKey
VOMKSBFLAZZBOW-UHFFFAOYSA-N- Summenformel
- C39H57FN4O4
- Durchschnittliche Molmasse
- 664,9 g/mol
Überblick
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate is a fatty acid ester obtained by the formal condensation of the carboxy group of hexadecanoic acid with the hydroxy group of 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one. It is a fatty acid ester, an organofluorine compound, a pyridopyrimidine, a heteroarylpiperidine and a member of 1,2-benzoxazoles.
Namen und Bezeichner
- Bevorzugter Name
- Paliperidone Palmitate
- IUPAC
- [3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl] hexadecanoate
- Englischer Name
- Paliperidone PalMitate-d4
- Summenformel
- C39H57FN4O4
- Molmasse
- 664.91
Namen und Synonyme
Paliperidone Palmitate199739-10-1Invega SustennaxeplionInvega TrinzaRo 92670RO92670R8P8USM8FRRo-92670ERZOFRIJNS010JNS-010
Weitere Namen anzeigen
RO 92670-d4Invega Sustenna-d4Mepanipyrim Impurity 4Paliperidone PalMitate-d4Paliperidone-D4 palmitate[2H4]-Paliperidone Palmitate9-Hydroxyrisperidone PalMitate-d4Hexadecanoic Acid 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl](ethyl-d4)]-6,7,8,9-tetrahydro-2-Methyl-4-oxo-4H-pyrido[1,2-a]pyriMidin-9-yl Ester
PALIPERIDONE JANSSENHexadecanoic acid, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido(1,2-a)pyrimidin-9-yl esterHexadecanoic acid, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl esterR-092670(9RS)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidin-9-yl hexadecanoateSustenna, Invega(9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl hexadecanoateINVEGA HAFYERA
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 10,1
- Polarare Oberfläche (TPSA)
- 88,2 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 20
- Schwere Atome
- 48
- Formalladung
- 0
- Komplexität
- 1.090
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 106 · 106-108°C
- storage temp.
- Refrigerator
- Löslichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Light Beige
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P260, P263, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 23 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
PALIPERIDONE PALMITATE
Atypical Antipsychotic [EPC]
MeSH Pharmacological Classification
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
Drugs that bind to but do not activate SEROTONIN 5-HT2 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT2 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more specific 5-HT2 receptor subtypes.
Compounds and drugs that bind to and inhibit or block the activation of DOPAMINE D2 RECEPTORS.
Anwendungen
VerwendenLike the labelled analogue of a long-acting injectable atypical antipsychotic, Paliperidone PalMitate-d4 can be used in the treatment of schizophrenia.
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