Arn19874
Grundinformationen
- CAS
2190502-57-7- Standard-SMILES
O=c1[nH]c(=O)c2cc(S(=O)(=O)Nc3ccc(-c4ccncc4)cc3)ccc2[nH]1- InChIKey
OPBGIIQHYNFABO-UHFFFAOYSA-N- Summenformel
- C19H14N4O4S
- Durchschnittliche Molmasse
- 394,4 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Arn19874
- IUPAC
- 2,4-dioxo-N-(4-pyridin-4-ylphenyl)-1H-quinazoline-6-sulfonamide
- Englischer Name
- ARN19874
- Summenformel
- C19H14N4O4S
- Molmasse
- 394.4
Namen und Synonyme
ARN198742,4-dioxo-N-(4-pyridin-4-ylphenyl)-1H-quinazoline-6-sulfonamideRefChem:9162172190502-57-7CHEMBL4746648HY-118994CS-00783392,4-dioxo-N-[4-(pyridin-4-yl)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide2,4-Dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6- sulfonamide2,4-Dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamideorb1707642GTPL11055
Weitere Namen anzeigen
ARN19874 (ARN-19874)6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(4-pyridinyl)phenyl]-
EX-A9461QMD50257BDBM50557069AKOS040741164DA-71038T143212,4-Dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-1,2,3,4-tetrahydro-2,4-dioxo-N-[4-(4-pyridinyl)phenyl]-6-quinazolinesulfonamide
Datenbank-Bezeichner
- CAS
2190502-57-7- ChEMBL
CHEMBL4746648- Nikkaji
- J3.699.319G
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 1,5
- Polarare Oberfläche (TPSA)
- 126 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 28
- Formalladung
- 0
- Komplexität
- 693
Physikochemische Eigenschaften
- Dichte
- 1.466 · 1.466±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 1 mg/ml · DMSO: 1 mg/ml
- Aggregatzustand
- A crystalline solid
- pka
- 7.44 · 7.44±0.20(Predicted)
- Farbe
- Off-white to pink
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological ClassificationCompounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Anwendungen
BeschreibungARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD; IC50 = 33.7 μM). It is selective for NAPD-PLD over carbonic anhydrase II, neutral endopeptidase, and angiotensin-converting enzyme (ACE) up to 50 μM. ARN19874 (50 μM) increases the levels of certain NAPE substrates and decreases the endogenous levels of stearoyl ethanolamide , but not oleoyl ethanolamide or palmitoyl ethanolamide , in HEK293 cells.
Anbieter13 Anbieter
沈阳中申泽康生物医学技术研究有限公司024-88590548 18698872706 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海林栎生物科技有限公司13761635123 · [email protected]
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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