Pirbuterol
Grundinformationen
- CAS
146621-69-4- Standard-SMILES
CC(C)(C)NCC(O)c1ccc(O)c(CO)n1- InChIKey
VQDBNKDJNJQRDG-UHFFFAOYSA-N- Summenformel
- C12H20N2O3
- Durchschnittliche Molmasse
- 240,3 g/mol
Überblick
Pirbuterol is a member of pyridines.
Namen und Bezeichner
- Bevorzugter Name
- Pirbuterol
- IUPAC
- 6-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)pyridin-3-ol
- Englischer Name
- pirbuterol
- Summenformel
- C12H20N2O3
- Molmasse
- 240.3
Namen und Synonyme
PIRBUTEROL38677-81-5Pirbuterolum6-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)pyridin-3-olOG645J8RVWARA-211Ethanol, 2-tert-butylamino-1-(5-hydroxy-6-hydroxymethyl-2-pyridyl)-pyrbuterolDTXSID0046937pirbuteroloCP-24315-16-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)pyridin-3-ol
Weitere Namen anzeigen
2,6-Pyridinedimethanol, α6-[[(1,1-dimethylethyl)amino]methyl]-3-hydroxy-, (-)-
(+-)-PirbuterolRefChem:863636DTXCID8026937R03CC07Pirbuterolum [INN-Latin](+/-)-PirbuterolPirbuterol (INN)PIRBUTEROL [INN]
Datenbank-Bezeichner
- CAS
146621-69-4- ChEMBL
CHEMBL1094966- ChEBI
CHEBI:8245- UNII
- OG645J8RVW
- Nikkaji
- J16.427E
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -0,1
- Polarare Oberfläche (TPSA)
- 85,6 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 5
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 17
- Formalladung
- 0
- Komplexität
- 230
Experimentelle und physikochemische Eigenschaften
Solubility6.22e+00 g/L
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anti-Asthmatic Agents; Bronchodilator Agents; Beta Adrenergic Agonists
Pharmaceuticals
Physical DescriptionSolid
Physikochemische Eigenschaften
- Siedepunkt
- 489.3 · 489.3±40.0 °C(Predicted)
- Dichte
- 1.196 · 1.196±0.06 g/cm3(Predicted)
- pka
- 8 · 8.00±0.10(Predicted)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Toxikologische Informationen
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Chemie und Industrie
Pharmakologische Informationen
ATC Code
R - Respiratory system
R - Respiratory system
QR - Respiratory system
QR - Respiratory system
Pharmacodynamics
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established.
Mechanism of Action
The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Biological Half-Life2 hours.
FDA Pharmacological Classification
OG645J8RVW
PIRBUTEROL
Mechanisms of Action [MoA] - Adrenergic beta2-Agonists
Established Pharmacologic Class [EPC] - beta2-Adrenergic Agonist
Pirbuterol is a beta2-Adrenergic Agonist. The mechanism of action of pirbuterol is as an Adrenergic beta2-Agonist.
MeSH Pharmacological Classification
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
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