Sulfaguanidine
Grundinformationen
- CAS
61116-95-8- Standard-SMILES
NC(N)=NS(=O)(=O)c1ccc(N)cc1- InChIKey
BRBKOPJOKNSWSG-UHFFFAOYSA-N- Summenformel
- C7H10N4O2S
- Durchschnittliche Molmasse
- 214,25 g/mol
Überblick
Sulfaguanidine is a sulfonamide incorporating a guanidine moiety used to block the synthesis of folic acid; mostly used in veterinary medicine. It has a role as an antiinfective agent.
Namen und Bezeichner
- Bevorzugter Name
- Sulfaguanidine
- IUPAC
- 2-(4-aminophenyl)sulfonylguanidine
- Englischer Name
- 2-(4-aminophenyl)sulfonylguanidine
- Summenformel
- C7H10N4O2S
- Molmasse
- 0
Namen und Synonyme
sulfaguanidine57-67-0SulphaguanidineSulfaguanidinSulfaguineSulfanilylguanidineSulfanilguanidineSulfaguanilSulfoguanidineSulfoguanilSulfoguanyl2-(4-aminophenyl)sulfonylguanidine
Weitere Namen anzeigen
Ai3-01048
SulfaguanidinaSulfaguanidinumBenzenesulfonamide, 4-amino-N-(aminoiminomethyl)-SulginumDTXSID1023609NSC-140412-sulfanilylguanidineDTXCID103609
Datenbank-Bezeichner
- CAS
61116-95-8- ChEMBL
CHEMBL338802- ChEBI
CHEBI:94621- UNII
- 15XQ8043FN
- EC Number
- 200-345-9
- Nikkaji
- J2.328K
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -0,7
- Polarare Oberfläche (TPSA)
- 133 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 14
- Formalladung
- 0
- Komplexität
- 307
Experimentelle und physikochemische Eigenschaften
Drugs
Pharmaceuticals -> Antibiotics
Pharmaceuticals -> Antibiotics (Sulfonamide)
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
PesticidesBiocide
LogP-1.22
Solubility>32.1 [ug/mL] (The mean of the results at pH 7.4)
Animal DrugsPharmaceuticals -> Animal Drugs -> Approved in Taiwan
Collision Cross Section149 Ų [M+H]+
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 4.9% (4 of 81) of reports.
Warning
H315 (92.6%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 81 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Status: Active Update: 26-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23557
Sulphaguanidine: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Benzenesulfonamide, 4-amino-N-(aminoiminomethyl)-: Human health tier I assessment
Hazard Classes and CategoriesSkin Irrit. 2 (92.6%)
Chemie und Industrie
Pharmakologische Informationen
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Mechanism of ActionSulfaguanidine is a sulfonamide antibacterial that inhibits dihydropteroate synthase (DHPS) by acting as a PABA analogue, blocking folate biosynthesis in susceptible microbes.
MeSH Pharmacological ClassificationSubstances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Verwendung und Herstellung
Use ClassificationPharmaceuticals -> Animal Drugs -> Approved in Taiwan
General Manufacturing InformationBenzenesulfonamide, 4-amino-N-(aminoiminomethyl)-: ACTIVE
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