Perindoprilat
Grundinformationen
- CAS
1356841-18-3- Standard-SMILES
CCC[C@H](N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C(=O)O- InChIKey
ODAIHABQVKJNIY-PEDHHIEDSA-N- Summenformel
- C17H28N2O5
- Durchschnittliche Molmasse
- 340,4 g/mol
Überblick
Perindoprilat is a dipeptide obtained by formal condensation of one of the carboxy groups of N-[(1S)-1-carboxyethyl]-L-norvaline with the amino group of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. The major active metabolite of perindopril. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, an antihypertensive agent and a drug metabolite. It is an organic heterobicyclic compound, a dicarboxylic acid, a dipeptide and a L-alanine derivative.
Namen und Bezeichner
- Bevorzugter Name
- Perindoprilat
- IUPAC
- (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
- Englischer Name
- ODAIHABQVKJNIY-NREMRFMJSA-N
- Summenformel
- C17H28N2O5
- Molmasse
- 340.42
Namen und Synonyme
Perindoprilat95153-31-4PerindoprilatePerindoprilatoPerindoprilatumS-97802UV6ZNQ92KS 9780DTXSID90869249CHEBI:132041(2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acidPerindopril diacid
Weitere Namen anzeigen
D4-PerindoprilatPerindoprilat acetate saltPerindoprilat-D4 (Standard)ODAIHABQVKJNIY-NREMRFMJSA-NPerindopril EP Impurity B-d4 (Perindoprilat-d4)Perindoprilat-d4 Discontinued. Please see P287534 or P287537.Perindopril EP Impurity B-d4 (Perindopril USP Related Compound B-d4 (Free Hydrate), Perindoprilat-d4)Perindoprilat D4Q: What is Perindoprilat D4 Q: What is the CAS Number of Perindoprilat D4 Q: What is the storage condition of Perindoprilat D4
(2S,3aS,7aS)-1-((2S)-2-(((2S)-1-hydroxy-1-oxopentan-2-yl)amino)propanoyl)-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acidRefChem:57070DTXCID10820872(2S,3aS,7aS)-1-((2S)-2-(((1S)-1-carboxybutyl)amino)propanoyl)-octahydro-1H-indole-2-carboxylic acid(2S,3aS,7aS)-1-((S)-2-(((S)-1-carboxybutyl)amino)propanoyl)octahydro-1H-indole-2-carboxylic acidPerindopril diacid form(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid(2S,3aS,7aS)-1-(((S)-1-carboxybutyl)-L-alanyl)octahydro-1H-indole-2-carboxylic acid
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 0,2
- Polarare Oberfläche (TPSA)
- 107 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 24
- Formalladung
- 0
- Komplexität
- 495
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals -> Metabolite of Perindopril
Physikochemische Eigenschaften
- Schmelzpunkt
- 153 · 153-155C
- storage temp.
- -20 °C · Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- Löslichkeit
- DMSO, Methanol
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H361d (100%): Suspected of damaging the unborn child [Warning Reproductive toxicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesRepr. 2 (100%)
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
2UV6ZNQ92K
PERINDOPRILAT
Established Pharmacologic Class [EPC] - Angiotensin Converting Enzyme Inhibitor
Mechanisms of Action [MoA] - Angiotensin-converting Enzyme Inhibitors
Perindoprilat is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of perindoprilat is as an Angiotensin-converting Enzyme Inhibitor.
MeSH Pharmacological Classification
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Tissue LocationsKidney
Cellular LocationsCytoplasm
Metabolite PathwaysPerindopril Action Pathway
Anwendungen
VerwendenAn angiotensin-converting enzyme (ACE) inhibitor.
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