Eicosapentaenoyl 1-Propanol-2-amide
Grundinformationen
- CAS
1638355-66-4- Standard-SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NC(C)CO- InChIKey
XOYVLIGJHWVUFH-JEBPEJKESA-N- Summenformel
- C23H37NO2
- Durchschnittliche Molmasse
- 359,5 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Eicosapentaenoyl 1-Propanol-2-amide
- IUPAC
- (5Z,8Z,11Z,14Z,17Z)-N-(1-hydroxypropan-2-yl)icosa-5,8,11,14,17-pentaenamide
- Englischer Name
- Eicosapentaenoyl 1-propanol-2-amide
- Summenformel
- C23H37NO2
- Molmasse
- 359.55
Namen und Synonyme
Eicosapentaenoyl 1-Propanol-2-amide1638355-66-4(5Z,8Z,11Z,14Z,17Z)-N-(1-HYDROXYPROPAN-2-YL)ICOSA-5,8,11,14,17-PENTAENAMIDEEicosapentaenoyl1-Propanol-2-amideorb1693748CHEMBL3358296AKOS040755251HY-139272H84877T36426(5Z,8Z,11Z,14Z,17Z)-N-(2-hydroxy-1-methyl-ethyl)icosa-5,8,11,14,17-pentaenamide(5Z,8Z,11Z,14Z,17Z)-N-(2-Hydroxy-1-methylethyl)-5,8,11,14,17-eicosapentaenamide
Weitere Namen anzeigen
5,8,11,14,17-Eicosapentaenamide, N-(2-hydroxy-1-methylethyl)-, (5Z,8Z,11Z,14Z,17Z)-
Datenbank-Bezeichner
- CAS
1638355-66-4- ChEMBL
CHEMBL3358296
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 5,1
- Polarare Oberfläche (TPSA)
- 49,3 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 15
- Schwere Atome
- 26
- Formalladung
- 0
- Komplexität
- 473
Physikochemische Eigenschaften
- Siedepunkt
- 529.1 · 529.1±50.0 °C(Predicted)
- Dichte
- 0.945 · 0.945±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 30 mg/ml; · DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
- pka
- 14.51 · 14.51±0.10(Predicted)
Chemie und Industrie
Anwendungen
BeschreibungMonoacylglycerols (MAGs) of ω-3 polyunsaturated fatty acids have diverse physiological and health effects. In particular, MAGs containing docosahexaenoic acid or eicosapentaenoic acid (EPA; ) have anti-proliferative properties against colon and lung cancer cell lines. Eicosapentaenoyl 1-propanol-2-amide is an EPA-containing MAG amide analog that inhibits the growth of human lung carcinoma A549 cells, producing 98.4% growth inhibition when applied at 3 μM. It is an analog of eicosapentaenoyl ethanolamide (Item No. 10964), a natural N-acylethanolamide that impacts aging and inflammation.
VerwendenEicosapentaenoyl 1-propanol-2-amide is an EPA-containing MAG amide analog that inhibits the growth of human lung carcinoma A549 cells. It is an analog of eicosapentaenoyl ethanolamide, a natural N-acylethanolamide that impacts aging and inflammation.
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