Glucosylsphingosine-plant
Grundinformationen
- CAS
114200-59-8- Standard-SMILES
CCCCCCCCCC=CCCC=CC(O)C(N)COC1OC(CO)C(O)C(O)C1O- InChIKey
HWRVJNPAUIAOKZ-UHFFFAOYSA-N- Summenformel
- C24H45NO7
- Durchschnittliche Molmasse
- 459,6 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Glucosylsphingosine-plant
- IUPAC
- 2-(2-amino-3-hydroxyoctadeca-4,8-dienoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
- Englischer Name
- 1--D-Glucosylsphingadienine (d18:2 (4E,8E))
- Summenformel
- C24H45NO7
- Molmasse
- 459.62
Namen und Synonyme
Glucosylsphingosine - plantorb1692207PEA20059PD0649011-β-D-Glucosylsphingadienine1--D-Glucosylsphingadienine (d18:2 (4E,8E))1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))2S-amino-3R-hydroxy-4E,8E-octadecadienyl,β-D-glucopyranosideβ-D-Glucopyranoside, (2S,3R,4E,8E)-2-amino-3-hydroxy-4,8-octadecadienyl (9CI)
Datenbank-Bezeichner
- CAS
114200-59-8
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,8
- Polarare Oberfläche (TPSA)
- 146 Ų
- H-Brücken-Donoren
- 6
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 17
- Schwere Atome
- 32
- Formalladung
- 0
- Komplexität
- 517
Physikochemische Eigenschaften
- Siedepunkt
- 665.495 · 665.495±55.00 °C(Press: 760.00 Torr)(predicted)
- Dichte
- 1.159 · 1.159±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- Chloroform:Methanol (4:1): Soluble
- Aggregatzustand
- A solid
- pka
- 11.98 · 11.980±0.45(predicted)
Chemie und Industrie
Anwendungen
Beschreibung1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides (Item Nos. 23206 | 23207). They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher''s disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-β-D-glucosylsphingadienine isolated from plants. [Matreya, LLC. Catalog No. 1310]
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