1-Dodecanethiol

Fire Extinguishing Agents Not to Be Used: Water or foam may cause frothing.

Use powder, AFFF, foam, carbon dioxide.

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

(General first aid procedures)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Ventilation control: adequate ventilation is of particular concern for hazardous materials that have high vapor pressure (such as...mercaptans). /mercaptans/

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet or significantly contaminated should be removed and replaced.

For more Preventive Measures (Complete) data for 1-DODECANETHIOL (8 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1.1X10+4(SRC), determined from a structure estimation method(2), indicates that 1-dodecanethiol is expected to be immobile in soil(SRC). Volatilization of 1-dodecanethiol from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.9X10-2 atm-cu m/mole(SRC), using a fragment constant estimation method(3). However, adsorption to soil is expected to attenuate volatilization(SRC). 1-Dodecanethiol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.53X10-3 mm Hg(4). Biodegradation data were not available(SRC, 2005).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1.1X10+4(SRC), determined from a structure estimation method(2), indicates that 1-dodecanethiol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 5.9X10-2 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hours and 6 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 77 days if adsorption is considered(5). According to a classification scheme(6), an estimated BCF of 360(SRC), from an estimated log Kow of 6.2(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is moderate (SRC). Biodegradation data were not available(SRC, 2005).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-dodecanethiol, which has a vapor pressure of 8.53X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-dodecanethiol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 7 hours(SRC), calculated from its rate constant of 5.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 1-Dodecanethiol does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Cough. Headache. Nausea. Sore throat.

Redness.

Redness. Pain.

Nausea. Vomiting. Headache. Abdominal pain. Diarrhoea.

irritation eyes, skin, respiratory system; cough; dizziness, dyspnea (breathing difficulty), lassitude (weakness, exhaustion), confusion, cyanosis; abdominal pain, nausea; skin sensitization

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-dodecanethiol can be estimated to be 1.1X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-dodecanethiol is expected to be immobile in soil.

Teratogenicity was evaluated in pregnant female Charles River CD-1 mice (25/group) exposed by inhalation to n-dodecyl mercaptan at concentrations of 0 and 7.4 ppm for 6 hrs/day on gestation days (GD) 6-16. Cesarean sections were performed on all surviving mice on GD 17. Significant differences were observed between treated and control animals in the following: maternal mortality (19 mice died on GD 13-16, one was sacrificed in extremis on GD 16, remaining mice, which exhibited signs of extreme toxicity, were sacrificed on GD 15-16), necropsy observations (including black discoloration of the intestines, colored fluid in the stomach or intestines, and absence of stomach contents), and incidence of whole litter resorptions (7 of 20 gravid females). Since no treated animals survived to the end of the study, no comparisons between treated and control animals can be made with respect to: maternal body weight and weight gain (weight loss was observed in treated animals), GD 17 Cesarean observations, and fetal morphological examination (since the fetuses were obtained prematurely, the skeletons were partially- or non-ossified).

Teratogenicity was evaluated in pregnant female Charles River COBS CD rats (25/group) exposed by inhalation to n-dodecyl mercaptan at concentrations of 0 and 7.4 ppm for 6 hrs/day on gestation days (GD) 6-19. Cesarean sections were performed on all surviving mice on GD 20. Significant differences were observed between treated and control animals in the following: increased incidence of hair loss, reddened conjunctivae, dry brown or black material around the nose, dry, peeling skin, thinness, and a pronounced reduction in maternal body weight gain. No significant differences were observed between treated and control animals in the following: necropsy examination, mean number of viable fetuses, postimplantation loss, total implantations, corpora lutea, fetal body weight, fetal sex ratio, fetal malformations, and genetic and developmental variations.

/SIGNS AND SYMPTOMS/ Liquid is irritating to...mucous membranes. Ingestion may cause nausea. Repeated skin exposure can cause dermatitis... Irritating concentration of vapor unlikely, but mist can cause irritation of...upper respiratory tract. If spilled on clothing and allowed to remain, may cause smarting and reddening of the skin.

/SIGNS AND SYMPTOMS/ Ingestion /may cause/... vomiting, headache, abdominal pain, and diarrhea.

/SIGNS AND SYMPTOMS/ Repeated or prolonged contact /with/ 1-Dodecanethiol may cause skin sensitization.

/SIGNS AND SYMPTOMS/ Inhalation /may cause/ cough, headache, nausea, and sore throat.

/OTHER TOXICITY INFORMATION/ ...Workers exposed to mixt /including 1-dodecanethiol/...with polychloroprene latexes have shown a significant increase in frequency of chromosomal aberrations in the peripheral blood.

1-Dodecanethiol's production and use in pharmaceuticals, insecticides, nonionic detergents, synthetic rubber processing, and as a froth flotation agent for metal refining(1) may result in its release to the environment through various waste streams(SRC).

SEDIMENT: 1-Dodecanethiol was detected from sites adjacent to the 102nd St. Dump site, Bloody Run Creek, and Gill Creek hazardous waste disposal areas in Niagara Falls, NY at concentrations of 3 ppm, not detected (detection limit = 0.5 ppm in sediment), and not detected, respectively, sampled in June and November, 1979(1). The dumps are in the vicinity of Love Canal(1).

An estimated BCF of 360 was calculated for 1-dodecanethiol(SRC), using an estimated log Kow of 6.18(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC), provided the compound is not metabolized by the organism(SRC).

The Henry's Law constant for 1-dodecanethiol is estimated as 5.9X10-2 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 1-dodecanethiol is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 6 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 77 days if adsorption is considered(3). 1-Dodecanethiol's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC); however, the compound is reported as having extremely low volatility(4). 1-Dodecanethiol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.53X10-3 mm Hg(5).