methyl 2-hydroxy-2-[(1R,9R,12S,19S)-6-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2(7),3,5-trien-12-yl]acetate

BeschreibungAn alkaloid isolated from Aspidosperma cylindrocarpon, this base is laevoro· tatory with a specific rotation of [α]20D - 300°. In MeOH it gives an ultraviolet spectrum with absorption maxima at 213, 248 and 290 nm. A number of ester derivatives have been described including the N·formy1 with an indefinite melting point; specific rotation of [α]20D - 250° (c 0.002, MeOH) and an ultraviolet spectrum with absorption maxima at 219, 259 and 291 nm; the N·acetyl com· pound, m.p. 207-210°C, forming colourless crystals from MeOH and having [α]20D - 400° (c 0.002, MeOH) and an ultraviolet spectrum in MeOH with absorption maxima at 228, 256 and 289 nm with a shoulder at 281 nm; the O·xanthate, m.p. 45°C; [α]20D - 250° (c 0.002, MeOH); the N·benzoyl derivative, m.p. 215-6°C and [α]20D - 160° (c 0.0012, MeOH) and the N· cinnamoyl compound with m.p. 123-4°C and [α]20D- 384° (c 0.0042, MeOH).