Eliprodil
Grundinformationen
- CAS
127293-58-7- Standard-SMILES
OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1- InChIKey
GGUSQTSTQSHJAH-UHFFFAOYSA-N- Summenformel
- C20H23ClFNO
- Durchschnittliche Molmasse
- 347,9 g/mol
Überblick
Eliprodil is a racemate comprising equimolar amounts of (R)- and (S)-eliprodil. It is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist and an anti-ischaemic agent that exhibits neuroprotective properties. It has a role as a geroprotector, a calcium channel blocker, a NMDA receptor antagonist and a neuroprotective agent. It contains a (R)-eliprodil and a (S)-eliprodil.
Namen und Bezeichner
- Bevorzugter Name
- Eliprodil
- IUPAC
- 1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanol
- Englischer Name
- ELIPRODIL
- Molmasse
- 0
Namen und Synonyme
Eliprodil119431-25-3DTXSID1045744SL-820715YW62A6TW29DTXCID9025744CHEBI:917841-Piperidineethanol, alpha-(4-chlorophenyl)-4-(4-fluorophenyl)-, (+-)-1-(4-chlorophenyl)-2-{4-[(4-fluorophenyl)methyl]piperidin-1-yl}ethan-1-oleliprodilumSL 82.07151-(4-chlorophenyl)-2-(4-((4-fluorophenyl)methyl)piperidin-1-yl)ethan-1-ol
Weitere Namen anzeigen
A-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL1-(4-CHLORO-PHENYL)-2-[4-(4-FLUORO-BENZYL)-PIPERIDIN-1-YL]-ETHANOL1-PIPERIDINEETHANOL, A-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-
1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethan-1-ol(4-chlorophenyl)-4-((4-fluorophenyl)methyl)-1-piperidineethanolRefChem:590714Eliprodil [INN]C20H23ClFNO1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanolalpha-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanolMFCD00866651
Datenbank-Bezeichner
- CAS
127293-58-7- ChEMBL
CHEMBL28564- ChEBI
CHEBI:91784- UNII
- YW62A6TW29
- EC Number
- 634-251-8
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 4,5
- Polarare Oberfläche (TPSA)
- 23,5 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 24
- Formalladung
- 0
- Komplexität
- 359
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P273, P280, P305+P351+P338, P337+P317, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesEye Irrit. 2 (100%)
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
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