Aldehyde Reactive Probe (trifluoroacetate salt)
Grundinformationen
- CAS
627090-10-2- Standard-SMILES
NOCC(=O)NNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C(O)C(F)(F)F- InChIKey
YJYRTJQOEOYKFD-AEXHUXLESA-N- Summenformel
- C14H22F3N5O6S
- Durchschnittliche Molmasse
- 445,42 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Aldehyde Reactive Probe (trifluoroacetate salt)
- IUPAC
- 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N'-(2-aminooxyacetyl)pentanehydrazide;2,2,2-trifluoroacetic acid
- Englischer Name
- Aldehyde Reactive Probe (trifluoroacetate salt)
- Summenformel
- C14H22F3N5O6S
- Molmasse
- 445.41
Namen und Synonyme
627090-10-2Aldehyde Reactive Probe (trifluoroacetate salt)5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N'-(2-aminooxyacetyl)pentanehydrazide;2,2,2-trifluoroacetic acidAldehyde reactive probe (TFA)ALDEHYDE REACTIVE PROBE TFAN'-(2-(Aminooxy)acetyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanehydrazide 2,2,2-trifluoroacetateYJYRTJQOEOYKFD-AEXHUXLESA-Norb1694498C14H22F3N5O6SARP, 95%EX-A14768MFCD03427750
Weitere Namen anzeigen
Aldehyde Reactive ProbeARP [N-(AMinooxyacetyl)-N'-(D-biotinoyl) hydrazine, trifluoroacetic acid salt]
AKOS040754706PD019824HY-135136CS-0109562H67374T35575N-(Aminooxyacetyl)-N'-D-biotinoyl)hydrazine, 96%ARP [N-(AMinooxyacetyl)-N'-(D-biotinoyl) hydrazine, trifluoroacetic acid salt]
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 197 Ų
- H-Brücken-Donoren
- 6
- H-Brücken-Akzeptoren
- 11
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 29
- Formalladung
- 0
- Komplexität
- 519
Physikochemische Eigenschaften
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 20 mg/ml; · DMF: 20 mg/ml; DMSO: 15 mg/ml; PBS (pH 7.2): 3 mg/ml
- Aggregatzustand
- A crystalline solid
Chemie und Industrie
Anwendungen
BeschreibungDNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites. The biotin-tagged DNA can then be detected using common avidin-conjugated reporters such as avidin-HRP. The ARP method is highly sensitive, enabling detection of 2.4 AP sites per 1x107 nucleotides of DNA.
Anbieter19 Anbieter
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MedBio脉铂医药021-69568360 18916172912 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
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上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
深圳市丽晶生化科技有限公司0755-85201366 18938635012 · [email protected]
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