Fluphenazine N4'-oxide
Grundinformationen
- CAS
1431868-11-9- Standard-SMILES
[15NH2][13C@@H]([13CH2][13c]1[13cH][13c](I)[13c](Oc2cc(I)c(O)c(I)c2)[13c](I)[13cH]1)[13C](=O)O- InChIKey
XUIIKFGFIJCVMT-LPIUGHGLSA-N- Summenformel
- C15H11I4NO4
- Durchschnittliche Molmasse
- 786,8 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Fluphenazine N4'-oxide
- IUPAC
- (2S)-2-(15N)azanyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo(1,2,3,4,5,6-13C6)cyclohexa-1,3,5-trien-1-yl](1,2,3-13C3)propanoic acid
- Englischer Name
- L-Thyroxine-13C9,15N
- Summenformel
- C15H11I4NO4
- Molmasse
- 786.8
Namen und Synonyme
1431868-11-9Fluphenazine N4'-oxideL-Thyroxine-13C9,15NLevothyroxine-13C9-15NL-Thyroxine-13C6,15N(2S)-2-(15N)azanyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo(1,2,3,4,5,6-13C6)cyclohexa-1,3,5-trien-1-yl](1,2,3-13C3)propanoic acid4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol 1-OxideO-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine-carboxy,alpha,beta,1,2,3,4,5,6-13C9-15NThyroxine Carboxy,?,?,1,2,3,4,5,6-13C9,15NC15H11I4NO4orb1693785AKOS040755227
Weitere Namen anzeigen
Thyroxine Carboxy,α,β,1,2,3,4,5,6-13C9,15NThyroxine Carboxy,alpha,beta,1,2,3,4,5,6-13C9,15NO-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine-carboxy,α,β,1,2,3,4,5,6-13C9-15N
HY-18341S3CS-0638230T36383(2S)-2-(15N)azanyl-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-(1,2,3,4,5,6-13C6)cyclohexa-1,3,5-trien-1-yl](1,2,3-13C3)propanoic acid
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,4
- Polarare Oberfläche (TPSA)
- 92,8 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 5
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 24
- Formalladung
- 0
- Komplexität
- 420
Physikochemische Eigenschaften
- Dichte
- 2.636 · 2.636±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 0.14 mg/ml; · DMF: 0.14 mg/ml; DMSO: 2.5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
- Aggregatzustand
- A solid
Chemie und Industrie
Anwendungen
BeschreibungL-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism. Formulations containing L-thyroxine have been used in the treatment of hypothyroidism.
VerwendenThyroxine Carboxy,α,β,1,2,3,4,5,6-13C9,15N is 13C and 15N labeled analogue of Thyroxine (T425600), which is one of the thyroid hormones involved in the maintenance of metabolic homeostasis.
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