HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Amastatin hydrochloride
AMASTATIN · AMASTATIN HCL · AMASTATIN HYDROCHLORIDE · AMASTATIN HYDROCHLORIDE HYDRATE · H-(2S,3R)-AHMH-VAL-VAL-ASP-OH HCL · Amastatin hydrate hydrochloride · 4-formylphenyl-O-β-d-allopyranoside · N((2S 3R)3-AMINO-2-HXY-5-ME.HEXANOYL)-L&
Identifikatoren & physikalische Daten
| CAS No. | 100938-10-1 |
|---|---|
| Summenformel | C21H39ClN4O8 |
| Durchschnittliche Molmasse | 511 g/mol |
| Monoisotopische Masse | 510,2456419 g/mol |
| SMILES | CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)C(C)C)C(C)C.Cl |
| InChIKey | GBDUPCKQTDKNLS-PORDUOSCSA-N |
| PubChem CID | 180936 |
| EC No. | 805-363-6 |
| DTXSID | DTXSID70905856 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 208 |
|---|---|
| H-Brücken-Donoren | 8 |
| H-Brücken-Akzeptoren | 9 |
| Frei drehbare Bindungen | 14 |
| Schwere Atome | 34 |
| Formalladung | 0 |
| Komplexität | 710 |
| Schmelzpunkt | 202-205 °C |
| Lagerbedingungen | -20°C |
| Löslichkeit | methanol: 5 mg/mL, clear, colorless |
| Aggregatzustand | White to off-white powder. |
| Farbe | White to off-white |
| Biologische Quelle | synthetic (organic) |
| BRN | 8888370 |
| InChIKey | WBYDQJQQTMJMQH-AFROIDPFSA-N |
| SMILES | Cl[H].[H]O[H].CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O |
Sicherheit & Vorschriften
| GHS-Einstufung | Not Classified |
|---|---|
| Hazard Classes and Categories | Not Classified |
| F | 10 |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 2924190090 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Verwenden
Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 μg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 μM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.[Cayman Chemical]