2,2'-Oxybis(N,N-dimethyl)ethanamin

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:；SMALL FIRE: Dry chemical, CO2 or water spray.；LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.；FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Excerpt from NIOSH Pocket Guide for bis(2-(Dimethylamino)ethyl)ether:；Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.；Skin: WATER FLUSH IMMEDIATELY - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.；Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.；Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024)

(General first aid procedures)；Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.；Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.；Breathing: Respiratory support；Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Wear self contained breathing apparatus for fire fighting if necessary. Use water spray to cool unopened containers.[Sigma-Aldrich; Material Safety Data Sheet for Bis

Personal precautions: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.[Sigma-Aldrich; Material Safety Data Sheet for Bis

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:；ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.[Sigma-Aldrich; Material Safety Data Sheet for Bis

Work clothing that becomes wet or significantly contaminated should be removed and replaced.

The worker should immediately wash the skin when it becomes contaminated.

Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.[Sigma-Aldrich; Material Safety Data Sheet for Bis

For more Preventive Measures (Complete) data for Bis (2-dimethylaminoethyl) ether (7 total), please visit the HSDB record page.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:；IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.；SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.；FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

NIOSH；At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration:；(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode；(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus；Escape:；(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister；Any appropriate escape-type, self-contained breathing apparatus；Important additional information about respirator selection

0.05 [ppm]

0.15 [ppm]

8 hr Time Weighted Avg (TWA): 0.05 ppm; 15 min Short Term Exposure Limit (STEL): 0.15 ppm. Skin.

0.05 ppm [1997]

0.15 ppm [1997]

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 13(SRC), determined from a structure estimation method(2), indicates that bis (2-dimethylaminoethyl) ether is expected to have very high mobility in soil(SRC). However, the estimated pKa values of bis (2-dimethylaminoethyl) ether are 8.14 and 9.21(3), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization from moist soil is not expected because the compound exists as a cation and cations do not volatilize. Bis (2-dimethylaminoethyl) ether is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.75 mm Hg at 25 °C(SRC), determined from a fragment constant method(5). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(6) indicating that biodegradation is not a rapid environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 13(SRC), determined from a structure estimation method(2), indicates that bis (2-dimethylaminoethyl) ether is not expected to adsorb to suspended solids and sediment(SRC). The estimated pKa values of 8.14 and 9.21(3) indicate that bis (2-dimethylaminoethyl) ether will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. According to a classification scheme(4), an estimated BCF of 3(SRC), from an estimated log Kow of -0.54(5) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(7) indicating that biodegradation is not expected to be a rapid environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bis (2-dimethylaminoethyl) ether, which has an estimated vapor pressure of 0.75 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase bis (2-dimethylaminoethyl) ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6 hrs(SRC), calculated from its rate constant of 2.1X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Bis (2-dimethylaminoethyl) ether does not contain chromophores that absorb at wavelengths >290 nm(4), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of bis (2-dimethylaminoethyl) ether can be estimated to be 13(SRC). According to a classification scheme(2), this estimated Koc value suggests that bis (2-dimethylaminoethyl) ether is expected to have very high mobility in soil. However, the pKa values of bis (2-dimethylaminoethyl) ether are pKa1 = 8.14 and pKa2 = 9.21, indicating that this compound will almost entirely exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

/SIGNS AND SYMPTOMS/ Exposure to vapors in the workplace has been reported to cause glaucopsia, a blue-gray haziness of vision, probably due to transient corneal edema. This change is a temporary disturbance of vision caused by exposure to ... vapors. This results from a slight increase in corneal thickness with fogging of vision and appearance of halos. On removal from exposure, vision returns to normal in a few hours without subsequent eye injury.

An estimated BCF of 3 was calculated in fish for bis (2-dimethylaminoethyl) ether(SRC), using an estimated log Kow of -0.54(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). The compound is considered to have low bioconcentration potential using a partition coefficient test(4).

The estimated pKa values of 8.14 and 9.21(1) indicate that bis (2-dimethylaminoethyl) ether will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. Bis (2-dimethylaminoethyl) ether is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.75 mm Hg(SRC), determined from a fragment constant method(3).

/LABORATORY ANIMALS: Acute Exposure/ Unoccluded application of 10 uL of undiluted DMAEE to the skin of rabbits produced marked local necrosis. More serious skin lesions were produced when the material was kept on the skin under occlusive dressing for 4 hr.

/LABORATORY ANIMALS: Acute Exposure/ DMAEE was applied to the eyes of rabbits undiluted or as a 1%, 5%, or 15% aqueous solution. When administered undiluted, DMAEE produced extensive corneal injury, iritis, severe conjunctival irritation, and chemosis. A 15% solution did not produce a corneal injury and produced only mild conjunctivitis. No ocular effects were produced by a 1% solution.

/LABORATORY ANIMALS: Acute Exposure/ In rabbits, measurements of corneal thickness were made prior to exposure, several times on the day following exposure, and at 24, 48, and 72 hr after the exposure. Exposures were by inhalation for 2 hr at 0.1, 1, 5, 10, 12, 15, 25, or 30 ppm DMAEE. Concentration-related increases in corneal thickness in rabbits were observed immediately following the exposure at between 10 and 30 ppm of DMAEE, with the thickness generally reaching a maximum at 3 hr postexposure. Corneal dullness or no clearly defined corneal margin, conjunctival hyperemia, and discharge were observed, which generally corresponded to the changes in corneal thickness. No increased thickness was noted in rabbits exposed at 0.1 or 1.0 ppm. Although corneal dullness was observed in some rabbits exposed at 5 ppm, only very slight changes in thickness were noted.

/LABORATORY ANIMALS: Acute Exposure/ ... Groups of six female rats were exposed to air saturated with the vapors of DMAEE for 8 hr. No deaths occurred. Lacrimation and excess conjunctival irritation were observed.

For more Non-Human Toxicity Excerpts (Complete) data for Bis (2-dimethylaminoethyl) ether (10 total), please visit the HSDB record page.

The rate constant for the vapor-phase reaction of bis (2-dimethylaminoethyl) ether with photochemically-produced hydroxyl radicals has been estimated as 2.1X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 0.6 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Bis (2-dimethylaminoethyl) ether is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Bis (2-dimethylaminoethyl) ether does not contain chromophores that absorb at wavelengths >290 nm(3), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Chemical: Ethanamine, 2,2'-oxybis[N,N-dimethyl-

Ethanamine, 2,2'-oxybis[N,N-dimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanamine, 2,2'-oxybis[N,N-dimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 20-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/13873

Bis(2-(dimethylamino)ethyl) ether: Does not have an individual approval but may be used under an appropriate group standard